Literature DB >> 2985182

Comparative localization of neurotensin receptors on nigrostriatal and mesolimbic dopaminergic terminals.

R Quirion, C C Chiueh, H D Everist, A Pert.   

Abstract

Neurotensin (NT), a brain-gut peptide, possesses many biological actions similar to those reported for neuroleptics. Moreover, it has been shown that NT alters dopaminergic activity of both nigrostriatal and mesolimbic pathways. We now report that NT receptors are located on dopaminergic cell bodies in both systems. However, the proportion of NT receptors on presynaptic dopaminergic terminals appears to be different. NT receptor sites are mainly found on presynaptic dopaminergic terminals in the caudate-putamen while they are pre- and post-synaptically located in the nucleus accumbens and the olfactory tubercule. NT receptors differential localization in these two pathways could be used as a model to study the comparative physiology of various dopaminergic brain systems.

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Year:  1985        PMID： 2985182     DOI： 10.1016/0006-8993(85)91542-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  28 in total

1.  Neurotensin effects on evoked release of dopamine in slices from striatum, nucleus accumbens and prefrontal cortex in rat.

Authors:  E Hétier; A Boireau; P Dubédat; J C Blanchard
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-01       Impact factor: 3.000

Review 2.  The role of neurotensin in central nervous system pathophysiology: what is the evidence?

Authors:  Fannie St-Gelais; Claudia Jomphe; Louis-Eric Trudeau
Journal:  J Psychiatry Neurosci       Date:  2006-07       Impact factor: 6.186

Review 3.  Functional implications of glutamatergic projections to the ventral tegmental area.

Authors:  Stefanie Geisler; Roy A Wise
Journal:  Rev Neurosci       Date:  2008       Impact factor: 4.353

4.  Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra.

Authors:  H Boudin; D Pélaprat; W Rostène; V M Pickel; A Beaudet
Journal:  J Neurosci       Date:  1998-10-15       Impact factor: 6.167

Review 5.  Presynaptic regulation of dopaminergic transmission in the striatum.

Authors:  J Glowinski; A Chéramy; R Romo; L Barbeito
Journal:  Cell Mol Neurobiol       Date:  1988-03       Impact factor: 5.046

6.  High affinity neurotensin receptor mRNA distribution in rat brain and peripheral tissues. Analysis by quantitative RT-PCR.

Authors:  M Méndez; F Souazé; M Nagano; P A Kelly; W Rostène; P Forgez
Journal:  J Mol Neurosci       Date:  1997-10       Impact factor: 3.444

7.  Visualizing receptors for neurotransmitters in the human brain with autoradiography.

Authors:  J M Palacios; G Chinaglia; A Probst
Journal:  Neurosurg Rev       Date:  1989       Impact factor: 3.042

8.  Dopaminergic control of 125I-labeled neurotensin binding site density in corticolimbic structures of the rat brain.

Authors:  D Herve; J P Tassin; J M Studler; C Dana; P Kitabgi; J P Vincent; J Glowinski; W Rostene
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

9.  The striatal neurotensin receptor modulates striatal and pallidal glutamate and GABA release: functional evidence for a pallidal glutamate-GABA interaction via the pallidal-subthalamic nucleus loop.

Authors:  L Ferraro; T Antonelli; W T O'Connor; K Fuxe; P Soubrié; S Tanganelli
Journal:  J Neurosci       Date:  1998-09-01       Impact factor: 6.167

10.  Presynaptic action of neurotensin on dopamine release through inhibition of D(2) receptor function.

Authors:  Charbel S Fawaz; Philippe Martel; Damiana Leo; Louis-Eric Trudeau
Journal:  BMC Neurosci       Date:  2009-08-14       Impact factor: 3.288
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