Thierry Bensignor1, Jérémie H Lefevre2, Ben Creavin3, Najim Chafai1, Thomas Lescot4, Thévy Hor1, Clotilde Debove1, François Paye1, Pierre Balladur1, Emmanuel Tiret1, Yann Parc1. 1. Department of General and Digestive Surgery, Hôpital Saint-Antoine, Assistance Publique Hôpitaux de Paris, Sorbonne Université, 184 rue du Faubourg Saint-Antoine, 75012, Paris, France. 2. Department of General and Digestive Surgery, Hôpital Saint-Antoine, Assistance Publique Hôpitaux de Paris, Sorbonne Université, 184 rue du Faubourg Saint-Antoine, 75012, Paris, France. jeremie.lefevre@aphp.fr. 3. Department of Colorectal Surgery, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland. 4. Department of Surgical Intensive Care, Hôpital Saint-Antoine, Assistance Publique Hôpitaux de Paris, Sorbonne Université, 75012, Paris, France.
Abstract
BACKGROUND: Postoperative peritonitis (POP) following gastrointestinal surgery is associated with significant morbidity and mortality, with no clear management option proposed. The aim of this study was to report our surgical management of POP and identify pre- and perioperative risk factors for morbidity and mortality. METHODS: All patients with POP undergoing relaparotomy in our department between January 2004 and December 2013 were included. Pre- and perioperative data were analyzed to identify predictors of morbidity and mortality. RESULTS: A total of 191 patients required relaparotomy for POP, of which 16.8% required >1 reinterventions. The commonest cause of POP was anastomotic leakage (66.5%) followed by perforation (20.9%). POP was mostly treated by anastomotic takedown (51.8%), suture with derivative stoma (11.5%), enteral resection and stoma (12%), drainage of the leak (8.9%), stoma on perforation (8.4%), duodenal intubation (7.3%) or intubation of the leak (3.1%). The overall mortality rate was 14%, of which 40% died within the first 48 h. Major complications (Dindo-Clavien > 2) were seen in 47% of the cohort. Stoma formation occurred in 81.6% of patients following relaparotomy. Independent risk factors for mortality were: ASA > 2 (OR = 2.75, 95% CI = 1.07-7.62, p = 0.037), multiorgan failure (MOF) (OR = 5.22, 95% CI = 2.11-13.5, p = 0.0037), perioperative transfusion (OR = 2.7, 95% CI = 1.05-7.47, p = 0.04) and upper GI origin (OR = 3.55, 95% CI = 1.32-9.56, p = 0.013). Independent risk factors for morbidity were: MOF (OR = 2.74, 95% CI = 1.26-6.19, p = 0.013), upper GI origin (OR = 3.74, 95% CI = 1.59-9.44, p = 0.0034) and delayed extubation (OR = 0.27, 95% CI = 0.14-0.55, p = 0.0027). CONCLUSION: Mortality following POP remains a significant issue; however, it is decreasing due to effective and aggressive surgical intervention. Predictors of poor outcomes will help tailor management options.
BACKGROUND:Postoperative peritonitis (POP) following gastrointestinal surgery is associated with significant morbidity and mortality, with no clear management option proposed. The aim of this study was to report our surgical management of POP and identify pre- and perioperative risk factors for morbidity and mortality. METHODS: All patients with POP undergoing relaparotomy in our department between January 2004 and December 2013 were included. Pre- and perioperative data were analyzed to identify predictors of morbidity and mortality. RESULTS: A total of 191 patients required relaparotomy for POP, of which 16.8% required >1 reinterventions. The commonest cause of POP was anastomotic leakage (66.5%) followed by perforation (20.9%). POP was mostly treated by anastomotic takedown (51.8%), suture with derivative stoma (11.5%), enteral resection and stoma (12%), drainage of the leak (8.9%), stoma on perforation (8.4%), duodenal intubation (7.3%) or intubation of the leak (3.1%). The overall mortality rate was 14%, of which 40% died within the first 48 h. Major complications (Dindo-Clavien > 2) were seen in 47% of the cohort. Stoma formation occurred in 81.6% of patients following relaparotomy. Independent risk factors for mortality were: ASA > 2 (OR = 2.75, 95% CI = 1.07-7.62, p = 0.037), multiorgan failure (MOF) (OR = 5.22, 95% CI = 2.11-13.5, p = 0.0037), perioperative transfusion (OR = 2.7, 95% CI = 1.05-7.47, p = 0.04) and upper GI origin (OR = 3.55, 95% CI = 1.32-9.56, p = 0.013). Independent risk factors for morbidity were: MOF (OR = 2.74, 95% CI = 1.26-6.19, p = 0.013), upper GI origin (OR = 3.74, 95% CI = 1.59-9.44, p = 0.0034) and delayed extubation (OR = 0.27, 95% CI = 0.14-0.55, p = 0.0027). CONCLUSION: Mortality following POP remains a significant issue; however, it is decreasing due to effective and aggressive surgical intervention. Predictors of poor outcomes will help tailor management options.
Authors: Paraskevi C Fragkou; Hew D Torrance; Rupert M Pearse; Gareth L Ackland; John R Prowle; Helen C Owen; Charles J Hinds; Michael J O'Dwyer Journal: Crit Care Date: 2014-10-01 Impact factor: 9.097
Authors: Yoann Launey; Benjamin Duteurtre; Raphaëlle Larmet; Nicolas Nesseler; Audrey Tawa; Yannick Mallédant; Philippe Seguin Journal: World J Crit Care Med Date: 2017-02-04
Authors: María Heredia-Rodríguez; María Teresa Peláez; Inmaculada Fierro; Esther Gómez-Sánchez; Estefanía Gómez-Pesquera; Mario Lorenzo; F Javier Álvarez-González; Juan Bustamante-Munguira; José María Eiros; Jesús F Bermejo-Martin; José I Gómez-Herreras; Eduardo Tamayo Journal: Ann Intensive Care Date: 2016-04-18 Impact factor: 6.925
Authors: Sven Petersen; Markus Huber; Federico Storni; Gero Puhl; Alice Deder; Axel Prause; Joerg C Schefold; Dietrich Doll; Patrick Schober; Markus M Luedi Journal: J Clin Monit Comput Date: 2021-07-10 Impact factor: 1.977