Tianxiang Chen1,2, Jizhuang Luo3, Rui Wang3, Haiyong Gu3, Yu Gu4, Qingyuan Huang3, Yiyang Wang3, Jiajie Zheng3, Yunhai Yang1, Heng Zhao3. 1. Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China. 2. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325000, China. 3. Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China. 4. Department of Radiation Oncology, Shanghai Cancer Center, Fudan University, Shanghai 200030, China.
Abstract
BACKGROUND: This study aimed to evaluate the prognostic difference between limited resection and lobectomy among elderly patients with small size lung adenocarcinoma. METHODS: A total of 666 patients >65 years old with stage I lung adenocarcinoma and tumor size ≤2 cm were included. The patient survival was evaluated by disease-free survival (DFS) and overall survival (OS). Results: No DFS or OS advantage was found between the lobectomy and wedge resection groups when tumor sizes were ≤1 cm (DFS, P=0.112; OS, P=0.294). The wedge resection group had a significantly worse OS (P=0.041) than that in the lobectomy group when tumor sizes were >1 cm and ≤2 cm. CONCLUSIONS: We conclude that wedge resection may be a reasonable surgical choice for elderly patients with tumor sizes ≤1 cm.
BACKGROUND: This study aimed to evaluate the prognostic difference between limited resection and lobectomy among elderly patients with small size lung adenocarcinoma. METHODS: A total of 666 patients >65 years old with stage I lung adenocarcinoma and tumor size ≤2 cm were included. The patient survival was evaluated by disease-free survival (DFS) and overall survival (OS). Results: No DFS or OS advantage was found between the lobectomy and wedge resection groups when tumor sizes were ≤1 cm (DFS, P=0.112; OS, P=0.294). The wedge resection group had a significantly worse OS (P=0.041) than that in the lobectomy group when tumor sizes were >1 cm and ≤2 cm. CONCLUSIONS: We conclude that wedge resection may be a reasonable surgical choice for elderly patients with tumor sizes ≤1 cm.
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