| Literature DB >> 29848888 |
Zhenjiang Xia1,2,3, Lixin Wei1,2, Yuzhi Du1,2, Lulu Wang4,5,6, Jichun Han4,5,6, Qiangqiang He1,2,3, Haijuan Chen1,2,3, Xiaoyan Zou1,2,3, Huali Wu4,5,6, Jing Shang1,2,4,5,6.
Abstract
Zuotai is a drug containing mercury considered to be the king of Tibetan medicine. The biosafety of Zuotai led people's attention and so far little is known about the toxicity of Zuotai to mast cells. RBL-2H3 cells which used as an alternative model of mast cells were treated with Zuotai, β-HgS and positive drug Compound 48/80 respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the toxicity of drugs to RBL-2H3 cells. The degranulation of RBL-2H3 cells was studied from β-hexosaminidase, histamine, interleukin (IL)-4 and tumor necrosis factor-α (TNF-α). The result showed that Zuotai can affect the cytotoxicity and degranulation of RBL-2H3 cells and the results can provide reference for the toxicity evaluations of Tibetan medicine Zuotai.Entities:
Keywords: RBL-2H3 cell; Tibetan medicine; Zuotai; cytotoxicity; mercury
Mesh：
Substances：
Year: 2018 PMID： 29848888 DOI： 10.1248/cpb.c18-00014
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645