Javad Shahinfar1, Zakieh Keshavarzi2, Mojgan Ahmadi3, Saeid Barzegar4, Garivani Asieh5, Alireza Abbaspour6. 1. Department of Anesthesia, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran. 2. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran. 3. Department of Biology, Payamnoor University, Mashhad, Iran. 4. Department of Biochemistry and Hematology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran. 5. School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran. 6. Department of Biochemistry, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Abstract
OBJECTIVE: To investigate the role of oxidative stress in patients with senile cataract. STUDY DESIGN: Case-control study. PLACE AND DURATION OF STUDY: North Khorasan University of Medical Sciences, Bojnurd, Iran, from 2014 to 2015. METHODOLOGY: Non-randomised sampling was conducted on 74 patients with senile cataract and 79 healthy people. The oxidative stress level, glutathione peroxidase (GPx) and superoxide dismutase (SOD) enzymes were measured in serum. The results were analysed using SPSS software and followed by t-test analysis. P<0.05 was considered to be significant. RESULTS: The median activity of GPx and SOD antioxidant enzymes in patients with cataract, was higher than healthy people (p=0.018 and p<0.0001, respectively). Peroxide-antioxidant (PAB) levels in patients with cataract was significantly higher than in healthy people (p<0.0001). CONCLUSION: This study showed that despite the high level of oxidative stress in patients, the activity rate of GPx and SOD enzymes also increased.
OBJECTIVE: To investigate the role of oxidative stress in patients with senile cataract. STUDY DESIGN: Case-control study. PLACE AND DURATION OF STUDY: North Khorasan University of Medical Sciences, Bojnurd, Iran, from 2014 to 2015. METHODOLOGY: Non-randomised sampling was conducted on 74 patients with senile cataract and 79 healthy people. The oxidative stress level, glutathione peroxidase (GPx) and superoxide dismutase (SOD) enzymes were measured in serum. The results were analysed using SPSS software and followed by t-test analysis. P<0.05 was considered to be significant. RESULTS: The median activity of GPx and SOD antioxidant enzymes in patients with cataract, was higher than healthy people (p=0.018 and p<0.0001, respectively). Peroxide-antioxidant (PAB) levels in patients with cataract was significantly higher than in healthy people (p<0.0001). CONCLUSION: This study showed that despite the high level of oxidative stress in patients, the activity rate of GPx and SOD enzymes also increased.