AIM: Real-world evidence of charted treatment responses to cancer drug therapy was compared with medical record derived radiographic measurements of target lesions per Response Evaluation Criteria in Solid Tumors (RECIST). MATERIALS & METHODS: 15 physicians treating 59 metastatic Merkel cell cancer (mMCC) patients contributed patient-level data. A comparison of medical record reported best response with radiographic measurements per RECIST of pre- and post-treatment target lesions. RESULTS: RECIST response rates were significantly lower compared with medical record reported with a concordance of 43.2% (95% CI: 28.0-58.4%). CONCLUSION: Subjective assessment of tumor response collected via traditional chart abstraction may overestimate benefit and limit the potential role of real-world evidence in value-based care research. The use of target lesion measurements presents an attractive alternative that better aligns with trial results.
AIM: Real-world evidence of charted treatment responses to cancer drug therapy was compared with medical record derived radiographic measurements of target lesions per Response Evaluation Criteria in Solid Tumors (RECIST). MATERIALS & METHODS: 15 physicians treating 59 metastatic Merkel cell cancer (mMCC) patients contributed patient-level data. A comparison of medical record reported best response with radiographic measurements per RECIST of pre- and post-treatment target lesions. RESULTS: RECIST response rates were significantly lower compared with medical record reported with a concordance of 43.2% (95% CI: 28.0-58.4%). CONCLUSION: Subjective assessment of tumor response collected via traditional chart abstraction may overestimate benefit and limit the potential role of real-world evidence in value-based care research. The use of target lesion measurements presents an attractive alternative that better aligns with trial results.
Authors: Xinran Ma; Lawrence Bellomo; Ian Hooley; Tori Williams; Meghna Samant; Katherine Tan; Brian Segal; Ariel Bulua Bourla Journal: JAMA Netw Open Date: 2022-05-02
Authors: Gilles Salles; Stephen J Schuster; Luca Fischer; John Kuruvilla; Piers E M Patten; Bastian von Tresckow; Sonali Smith; Ana Jiménez Ubieto; Keith L Davis; Saurabh Nagar; Jie Zhang; Vamsi Bollu; Etienne Jousseaume; Roberto Ramos; Yucai Wang; Brian K Link Journal: Hemasphere Date: 2022-06-21