Cervical dysplasia: cytology class III D and CIN I-II.

Some aspects of class III D-smears (suggesting slight to moderate dysplasia) have been investigated. Results of a cytological follow-up in 481 patients and of the histological findings immediately or during the follow-up in 142 patients are presented. In 112 patients a triple cervical smear approach has been used to determine the rate of false negative smears and errors of sampling. This approach includes the preparation of three slides with cellular material obtained separately from the anterior cervical lip, the posterior lip and from the endocervical canal, using three cotton applicators. To compare the results of cytology with the grade of CIN in different areas of the conization specimens triple cervical smears have been taken preoperatively. Finally 28 patients with a conization following a class III D-smear have been investigated for HPV-induced cell changes which were found in six cases.