Literature DB >> 2984608

Evidence that the anticonflict effect of midazolam in amygdala is mediated by the specific benzodiazepine receptors.

E N Petersen, C Braestrup, J Scheel-Krüger.   

Abstract

The benzodiazepine midazolam produced an anticonflict effect in rats measured in a water lick paradigm following local injection into the basolateral and lateral complex of the amygdala. This effect of midazolam seems to involve specific benzodiazepine receptors, since the systemic injection of benzodiazepine antagonists Ro 15-1788, ZK 93426, FG 7142 and CGS 8216 produced strong antagonism of the effect of midazolam in doses not affecting the non-punished drinking behaviour.

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Year:  1985        PMID： 2984608     DOI： 10.1016/0304-3940(85)90552-x

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  10 in total

1.  Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice.

Authors:  Scott A Heldt; Kerry J Ressler
Journal:  J Neurosci       Date:  2010-05-26       Impact factor: 6.167

2.  Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure.

Authors:  M N Hill; S A Kumar; S B Filipski; M Iverson; K L Stuhr; J M Keith; B F Cravatt; C J Hillard; S Chattarji; B S McEwen
Journal:  Mol Psychiatry       Date:  2012-07-10       Impact factor: 15.992

3.  Localized injections of midazolam into the amygdala and hippocampus induce differential changes in anxiolytic-like motor activity in mice.

Authors:  Scott A Heldt; Kerry J Ressler
Journal:  Behav Pharmacol       Date:  2006-06       Impact factor: 2.293

4.  Basolateral amygdala lesions block diazepam-induced anterograde amnesia in an inhibitory avoidance task.

Authors:  C Tomaz; H Dickinson-Anson; J L McGaugh
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

5.  Effects of benzodiazepine and GABA antagonists on anticonflict effects of antianxiety drugs injected into the rat amygdala in a water-lick suppression test.

Authors:  S Shibata; K Yamashita; E Yamamoto; T Ozaki; S Ueki
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

6.  The role of amygdalar mu-opioid receptors in anxiety-related responses in two rat models.

Authors:  Marlene A Wilson; Lorain Junor
Journal:  Neuropsychopharmacology       Date:  2008-01-23       Impact factor: 7.853

7.  Training-induced changes in the expression of GABAA-associated genes in the amygdala after the acquisition and extinction of Pavlovian fear.

Authors:  Scott A Heldt; Kerry J Ressler
Journal:  Eur J Neurosci       Date:  2007-12       Impact factor: 3.386

8.  In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice.

Authors:  S A Heldt; L Mou; K J Ressler
Journal:  Transl Psychiatry       Date:  2012-11-13       Impact factor: 6.222

Review 9.  The role of the medial prefrontal cortex-amygdala circuit in stress effects on the extinction of fear.

Authors:  Irit Akirav; Mouna Maroun
Journal:  Neural Plast       Date:  2007-01-16       Impact factor: 3.599

10.  Differential effects of acute diazepam on emotional and neutral memory tasks in acutely hospitalized depressed patients.

Authors:  Vera B Delgado; Ivan Izquierdo; Márcia Lf Chaves
Journal:  Neuropsychiatr Dis Treat       Date:  2005-09       Impact factor: 2.570
  10 in total

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