Literature DB >> 29845928

Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017.

Thibault Poncin1,2, Sebastien Fouere3, Aymeric Braille1,2, Francois Camelena1,2,4, Myriem Agsous1,2, Cecile Bebear5, Sylvain Kumanski2, Florence Lot6, Severine Mercier-Delarue1, Ndeindo Ndeikoundam Ngangro6, Maud Salmona1, Nathalie Schnepf1,2, Julie Timsit3, Magnus Unemo7, Beatrice Bercot1,2,4.   

Abstract

We report a multidrug-resistant Neisseria gonorrhoeae urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST1903, NG-MAST ST3435, NG-STAR233, and relevant resistance determinants. F90 showed phenotypic and genotypic similarities to an internationally spreading multidrug-resistant and ceftriaxone-resistant clone detected in Japan and subsequently in Australia, Canada and Denmark.

Entities:  

Keywords:  antimicrobial resistance; antimicrobial treatment; diagnosis; gonorrhoea; treatment failure

Mesh：

Substances：

Year:  2018        PMID： 29845928      PMCID： PMC6152217          DOI： 10.2807/1560-7917.ES.2018.23.21.1800264

Source DB:  PubMed          Journal:  Euro Surveill        ISSN： 1025-496X


  17 in total

Review 1.  Review and international recommendation of methods for typing neisseria gonorrhoeae isolates and their implications for improved knowledge of gonococcal epidemiology, treatment, and biology.

Authors:  Magnus Unemo; Jo-Anne R Dillon
Journal:  Clin Microbiol Rev       Date:  2011-07       Impact factor: 26.132

2.  Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea.

Authors:  Helen Fifer; Usha Natarajan; Lucy Jones; Sarah Alexander; Gwenda Hughes; Daniel Golparian; Magnus Unemo
Journal:  N Engl J Med       Date:  2016-06-23       Impact factor: 91.245

3.  Azithromycin versus Doxycycline for Urogenital Chlamydia trachomatis Infection.

Authors:  William M Geisler; Apurva Uniyal; Jeannette Y Lee; Shelly Y Lensing; Shacondra Johnson; Raymond C W Perry; Carmel M Kadrnka; Peter R Kerndt
Journal:  N Engl J Med       Date:  2015-12-24       Impact factor: 91.245

4.  High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure.

Authors:  Magnus Unemo; Daniel Golparian; Robert Nicholas; Makoto Ohnishi; Anne Gallay; Patrice Sednaoui
Journal:  Antimicrob Agents Chemother       Date:  2011-12-12       Impact factor: 5.191

5.  Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing.

Authors:  Claire de Curraize; Sylvain Kumanski; Maïté Micaëlo; Nelly Fournet; Guy La Ruche; Fabienne Meunier; Rishma Amarsy; Hervé Jacquier; Emmanuelle Cambau; Agathe Goubard; Béatrice Bercot
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

6.  New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan.

Authors:  Shu-Ichi Nakayama; Ken Shimuta; Kei-Ichi Furubayashi; Takuya Kawahata; Magnus Unemo; Makoto Ohnishi
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

7.  Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain.

Authors:  Jordi Cámara; Judit Serra; Josefina Ayats; Teresa Bastida; Dolors Carnicer-Pont; Antònia Andreu; Carmen Ardanuy
Journal:  J Antimicrob Chemother       Date:  2012-05-07       Impact factor: 5.790

8.  Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action.

Authors:  Teodora Wi; Monica M Lahra; Francis Ndowa; Manju Bala; Jo-Anne R Dillon; Pilar Ramon-Pardo; Sergey R Eremin; Gail Bolan; Magnus Unemo
Journal:  PLoS Med       Date:  2017-07-07       Impact factor: 11.069

9.  Species status of Neisseria gonorrhoeae: evolutionary and epidemiological inferences from multilocus sequence typing.

Authors:  Julia S Bennett; Keith A Jolley; P Frederick Sparling; Nigel J Saunders; C Anthony Hart; Ian M Feavers; Martin C J Maiden
Journal:  BMC Biol       Date:  2007-09-07       Impact factor: 7.431

10.  In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae.

Authors:  Leah R Vincent; Samuel R Kerr; Yang Tan; Joshua Tomberg; Erica L Raterman; Julie C Dunning Hotopp; Magnus Unemo; Robert A Nicholas; Ann E Jerse
Journal:  mBio       Date:  2018-04-03       Impact factor: 7.867
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  25 in total

1.  High in vitro susceptibility to the first-in-class spiropyrimidinetrione zoliflodacin among consecutive clinical Neisseria gonorrhoeae isolates from Thailand (2018) and South Africa (2015-2017).

Authors:  Susanne Jacobsson; Ranmini Kularatne; Rossaphorn Kittiyaowamarn; Venessa Maseko; Porntip Paopang; Pongsathorn Sangprasert; Pachara Sirivongrangson; Laura Piddock; Teodora Wi; Emilie Alirol; Magnus Unemo
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

Review 2.  World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts.

Authors:  Magnus Unemo; Monica M Lahra; Michelle Cole; Patricia Galarza; Francis Ndowa; Irene Martin; Jo-Anne R Dillon; Pilar Ramon-Pardo; Gail Bolan; Teodora Wi
Journal:  Sex Health       Date:  2019-09       Impact factor: 2.706

3.  Structures of glyceraldehyde 3-phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis.

Authors:  Kayleigh F Barrett; David M Dranow; Isabelle Q Phan; Samantha A Michaels; Shareef Shaheen; Edelmar D Navaluna; Justin K Craig; Logan M Tillery; Ryan Choi; Thomas E Edwards; Deborah G Conrady; Jan Abendroth; Peter S Horanyi; Donald D Lorimer; Wesley C Van Voorhis; Zhongsheng Zhang; Lynn K Barrett; Sandhya Subramanian; Bart Staker; Erkang Fan; Peter J Myler; Olusegun O Soge; Kevin Hybiske; Kayode K Ojo
Journal:  Protein Sci       Date:  2020-01-28       Impact factor: 6.993

4.  Bacterial sexually transmitted infections in France: recent trends and patients' characteristics in 2016.

Authors:  Ndeindo Ndeikoundam Ngangro; Delphine Viriot; Nelly Fournet; Corinne Pioche; Bertille De Barbeyrac; Agathe Goubard; Nicolas Dupin; Béatrice Berçot; Sébastien Fouéré; Isabelle Alcaraz; Michel Ohayon; Nathalie Spenatto; Chantal Vernay-Vaisse; Josiane Pillonel; Florence Lot
Journal:  Euro Surveill       Date:  2019-01

5.  Authors' response: Prevention of bacterial sexually transmitted infections (STI) in France: a comprehensive approach.

Authors:  Ndeindo Ndeikoundam Ngangro; Annie Velter; Nathalie Lydie; Florence Lot
Journal:  Euro Surveill       Date:  2019-03

6.  In vitro activity of the novel oral antimicrobial SMT-571, with a new mechanism of action, against MDR and XDR Neisseria gonorrhoeae: future treatment option for gonorrhoea?

Authors:  Susanne Jacobsson; Clive Mason; Nawaz Khan; Paul Meo; Magnus Unemo
Journal:  J Antimicrob Chemother       Date:  2019-06-01       Impact factor: 5.790

7.  Emergence and Spread of Cephalosporin-Resistant Neisseria gonorrhoeae with Mosaic penA Alleles, South Korea, 2012-2017.

Authors:  Hyukmin Lee; Young Hee Suh; Sunhwa Lee; Yong-Kyun Kim; Mi-Soon Han; Hye Gyung Bae; Magnus Unemo; Kyungwon Lee
Journal:  Emerg Infect Dis       Date:  2019-03       Impact factor: 6.883

Review 8.  Bioinformatics tools used for whole-genome sequencing analysis of Neisseria gonorrhoeae: a literature review.

Authors:  Reema Singh; Anthony Kusalik; Jo-Anne R Dillon
Journal:  Brief Funct Genomics       Date:  2022-04-11       Impact factor: 4.840

9.  Genomic analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Vietnam in 2011 and 2015-16.

Authors:  Pham Thi Lan; Daniel Golparian; Johan Ringlander; Le Van Hung; Nguyen Van Thuong; Magnus Unemo
Journal:  J Antimicrob Chemother       Date:  2020-06-01       Impact factor: 5.790

10.  Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018.

Authors:  Daniel Golparian; Lisa Rose; Almida Lynam; Aia Mohamed; Beatrice Bercot; Makoto Ohnishi; Brendan Crowley; Magnus Unemo
Journal:  Euro Surveill       Date:  2018-11
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