Literature DB >> 2984582

In vivo demonstration of alpha-2-adrenoceptor-mediated inhibition of the excitatory non-cholinergic neurotransmission in guinea pig airways.

N Grundström, R G Andersson.   

Abstract

In anaesthetized guinea pigs, vagal nerve stimulation caused an atropine- and hexamethonium-resistant increase in the respiratory insufflation pressure. Clonidine (0.05 mg/kg i.v.) inhibited the increase in insufflation pressure caused by vagal stimulation. This effect of clonidine was antagonized by the alpha-2-antagonist yohimbine (0.5 mg/kg i.v.), but not by the alpha-1-antagonist prazosin (0.03 mg/kg i.v.). In conclusion, the increase in the respiratory insufflation pressure, caused by stimulation of noncholinergic nerves, seemed to be controlled by inhibitory alpha-2-adrenoceptors in guinea pig airways.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2984582     DOI： 10.1007/bf00515547

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  17 in total

1.  Nerve supply to the lungs.

Authors:  J B Richardson
Journal:  Am Rev Respir Dis       Date:  1979-05

2.  Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo.

Authors:  T L Yaksh; T M Jessell; R Gamse; A W Mudge; S E Leeman
Journal:  Nature       Date:  1980-07-10       Impact factor: 49.962

3.  Prejunctional alpha 2 adrenoceptors inhibit contraction of tracheal smooth muscle by inhibiting cholinergic neurotransmission.

Authors:  N Grundström; R G Andersson; J E Wikberg
Journal:  Life Sci       Date:  1981-06-29       Impact factor: 5.037

4.  Bronchial smooth muscle contraction induced by stimulation of capsaicin-sensitive sensory neurons.

Authors:  J M Lundberg; A Saria
Journal:  Acta Physiol Scand       Date:  1982-12

5.  Evidence that axons containing substance P in the guinea-pig ileum are of intrinsic origin.

Authors:  R Franco; M Costa; J B Furness
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-05       Impact factor: 3.000

6.  Inhibition of the excitatory non-adrenergic, non-cholinergic neurotransmission in the guinea pig tracheo-bronchial tree mediated by alpha 2-adrenoceptors.

Authors:  N Grundström; R G Andersson; J E Wikberg
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1984-01

7.  Capsaicin pretreatment inhibits vagal cholinergic and non-cholinergic control of pulmonary mechanics in the guinea pig.

Authors:  C R Martling; A Saria; P Andersson; J M Lundberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-04       Impact factor: 3.000

8.  Pharmacological characterization of the autonomous innervation of the guinea pig tracheobronchial smooth muscle.

Authors:  N Grundström; R G Andersson; J E Wikberg
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1981-08

9.  Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level.

Authors:  J L Hylden; G L Wilcox
Journal:  J Pharmacol Exp Ther       Date:  1983-08       Impact factor: 4.030

10.  A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig.

Authors:  J M Lundberg; A Saria; E Brodin; S Rosell; K Folkers
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205
View more
  13 in total

Review 1.  Potassium channels and airway function: new therapeutic prospects.

Authors:  J L Black; P J Barnes
Journal:  Thorax       Date:  1990-03       Impact factor: 9.139

2.  Proceedings of the British Pharmacological Society. University of Manchester, 13-15 September 1989.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

Review 3.  Airway receptors.

Authors:  P J Barnes
Journal:  Postgrad Med J       Date:  1989-08       Impact factor: 2.401

4.  Opioid modulation of non-cholinergic neural bronchoconstriction in guinea-pig in vivo.

Authors:  M G Belvisi; K F Chung; D M Jackson; P J Barnes
Journal:  Br J Pharmacol       Date:  1988-10       Impact factor: 8.739

5.  The effects of calcitonin gene-related peptide on tracheal smooth muscle of guinea-pigs in vitro.

Authors:  H Ninomiya; Y Uchida; T Endo; M Ohtsuka; A Nomura; M Saotome; S Hasegawa
Journal:  Br J Pharmacol       Date:  1996-12       Impact factor: 8.739

6.  Suppression by neuropeptide Y of capsaicin-sensitive sensory nerve-mediated contraction in guinea-pig airways.

Authors:  L Grundemar; N Grundström; I G Johansson; R G Andersson; R Håkanson
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

7.  Characterization of sensory neurotransmission and its inhibition via alpha 2B-adrenoceptors and via non-alpha 2-receptors in rabbit iris.

Authors:  H Fuder; M Selbach
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-04       Impact factor: 3.000

8.  Alpha-adrenoceptor modulation of the efferent function of capsaicin-sensitive sensory neurones in guinea-pig isolated atria.

Authors:  S Amerini; A Rubino; L Mantelli; F Ledda
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

9.  Modulation of non-adrenergic non-cholinergic inhibitory neurotransmission in rat gastric fundus by the alpha 2-adrenoceptor agonist, UK-14,304.

Authors:  R A Lefebvre; G J Smits
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

10.  Modulation of neurally mediated airway microvascular leakage in guinea-pig airways by beta 2-adrenoceptor agonists.

Authors:  K P Hui; P Ventresca; A C Brown; P J Barnes; K F Chung
Journal:  Agents Actions       Date:  1992-05
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.