H Brochard1, O Godin2,3,4, P A Geoffroy4,5,6,7, S Yeim5,6, C Boudebesse8, C Benizri9, V Benard7, J Maruani5, M Leboyer4,8,9, F Bellivier4,5,6,7, B Etain4,5,6,7. 1. Pôle sectoriel, Centre Hospitalier Fondation Vallée, Gentilly, France. 2. Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Sorbonne Universités, Université Pierre et Marie Curie, Paris, France. 3. INSERM, UMR_S 1136, Paris, France. 4. Fondation FondaMental, Créteil, France. 5. Département de Psychiatrie et de Médecine Addictologique, AP-HP, GH Saint-Louis - Lariboisière - F. Widal, Paris, France. 6. Sorbonne Paris Cité, Université Paris Diderot, Paris, France. 7. INSERM U1144, Paris, France. 8. AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie, Créteil, France. 9. Equipe Psychiatrie Translationnelle, INSERM U955, Créteil, France.
Abstract
OBJECTIVE: This study explored the correlations between sleep and circadian rhythm measures and the metabolic syndrome (MetS) components in remitted patients with bipolar disorder (BD). METHOD: Euthymic patients with BD (n = 67) were recorded by 3 weeks with actigraphy. We used nonparametric correlations to study the links between the MetS parameters, atherogenic index of plasma (AIP), sleep efficacy, sleep latency, fragmentation index, and phase and amplitude of rhythms. We performed multivariable analyses to take into account potential confounding factors such as sleep apnea risk, antipsychotics use, and smoker status. RESULTS: We found correlations between lower sleep efficiency and higher triglyceride levels (P = 0.002), lower M10 onset (beginning of the 10 most active hours during the 24-h cycle) and higher systolic blood pressure (P = 0.03), higher fragmentation index and higher systolic blood pressure (P = 0.009), lower sleep efficiency, higher fragmentation index, and higher AIP (respectively P = 0.02 and P = 0.04). These correlations mostly remained significant when adjusting for confounders, with the exception of M10 onset and systolic blood pressure. CONCLUSION: Sleep efficiency and fragmentation index might contribute to the cardiovascular risk of patients with BD independently of major confounding factors. Although these associations did not imply causality, proposing interventions on sleep quality and circadian rhythm regularity might contribute to reduce cardiovascular risk in patients with BD.
OBJECTIVE: This study explored the correlations between sleep and circadian rhythm measures and the metabolic syndrome (MetS) components in remitted patients with bipolar disorder (BD). METHOD: Euthymic patients with BD (n = 67) were recorded by 3 weeks with actigraphy. We used nonparametric correlations to study the links between the MetS parameters, atherogenic index of plasma (AIP), sleep efficacy, sleep latency, fragmentation index, and phase and amplitude of rhythms. We performed multivariable analyses to take into account potential confounding factors such as sleep apnea risk, antipsychotics use, and smoker status. RESULTS: We found correlations between lower sleep efficiency and higher triglyceride levels (P = 0.002), lower M10 onset (beginning of the 10 most active hours during the 24-h cycle) and higher systolic blood pressure (P = 0.03), higher fragmentation index and higher systolic blood pressure (P = 0.009), lower sleep efficiency, higher fragmentation index, and higher AIP (respectively P = 0.02 and P = 0.04). These correlations mostly remained significant when adjusting for confounders, with the exception of M10 onset and systolic blood pressure. CONCLUSION:Sleep efficiency and fragmentation index might contribute to the cardiovascular risk of patients with BD independently of major confounding factors. Although these associations did not imply causality, proposing interventions on sleep quality and circadian rhythm regularity might contribute to reduce cardiovascular risk in patients with BD.
Authors: Priyanka Panchal; Gabriela de Queiroz Campos; Danielle A Goldman; Randy P Auerbach; Kathleen R Merikangas; Holly A Swartz; Anjali Sankar; Hilary P Blumberg Journal: Front Psychiatry Date: 2022-05-23 Impact factor: 5.435
Authors: Thomas D Bjella; Margrethe Collier Høegh; Stine Holmstul Olsen; Sofie R Aminoff; Elizabeth Barrett; Torill Ueland; Romain Icick; Ole A Andreassen; Mari Nerhus; Henrik Myhre Ihler; Marthe Hagen; Cecilie Busch-Christensen; Ingrid Melle; Trine Vik Lagerberg Journal: Front Med Technol Date: 2022-07-22