| Literature DB >> 29845536 |
Eduardo Alves Dos Santos1, Katja Fink2.
Abstract
The current status of animal models in the study of dengue and Zika are covered in this review. Mouse models deficient in IFN signaling are used to overcome the natural resistance of mice to non-encephalitic flaviviruses. Conditional IFNAR mice and non-human primates (NHP) are useful immuno-competent models. Sterile immunity after dengue vaccination is not observed in NHPs. Placental and fetal development in NHPs is similar to humans, facilitating studies on infection-mediated fetal impairment.Entities:
Keywords: Conditional knockout IFNAR mouse model; Dengue animal models; Humanized mice for dengue and Zika vaccine testing; Non-IFN-receptor-based immuno-compromised mouse models; Zika non-human primate model
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Year: 2018 PMID： 29845536 DOI： 10.1007/978-981-10-8727-1_16
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622