Giuseppe Casalino 1,2 , Alessandro Arrigo 3 , Francesco Romano 3 , Marion R Munk 4 , Francesco Bandello 3 , Maurizio Battaglia Parodi 3 Show Affiliations »
Abstract
AIM: To describe the optical coherence tomography angiography (OCT-A) features of patients affected by acute macular neuroretinopathy (AMN). METHODS: This is a prospective, observational, cross-sectional study. Multimodal imaging, including spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany) and 6×6 mm swept source OCT-A (ZEISS PLEX Elite 9000; ZEISS, Dublin, California), was performed on all patients. The primary outcome measure was assessment of the vascular alterations of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC). A segmentation of the AMN lesions using enface OCT images of photoreceptors-retinal pigment epithelium complex was used to discriminate intralesional and extralesional regions on the OCT-A enface slabs of the DCP and CC reconstructions. Each OCT-A slab was imported into ImageJ V.1.50 and digitally binarised for quantitative analyses. RESULTS: Overall, seven patients (mean age 19.4±3.2 years, six women) affected by AMN were included. The mean best-corrected visual acuity was 0.00±0.00 logarithm of the minimum angle of resolution. Twelve healthy age-matched subjects (mean age 22±3.4 years, 10 women) represented the control group. The quantitative analysis of global vessel densities showed that the CC vessel density was significantly lower in patients with AMN (0.495±0.03) compared with the age-matched controls (0.545±0.02) (corrected p=0.0003). The intralesional vessel density of the DCP was 0.349±0.04 in AMN and vs 0.497±0.02 in the controls (corrected p=0.0002). CONCLUSIONS: Our study confirmed inner choroidal vascular flow void as a possible pathogenetic mechanism of AMN. We also found a focal impairment of the DCP within the AMN lesions. Future studies are needed to clarify which is the primary location of the vascular insult in this condition. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
AIM: To describe the optical coherence tomography angiography (OCT -A) features of patients affected by acute macular neuroretinopathy (AMN ). METHODS: This is a prospective, observational, cross-sectional study. Multimodal imaging, including spectral domain OCT (Spectralis HRA+OCT ; Heidelberg Engineering, Heidelberg, Germany) and 6×6 mm swept source OCT -A (ZEISS PLEX Elite 9000; ZEISS, Dublin, California), was performed on all patients . The primary outcome measure was assessment of the vascular alterations of the superficial (SCP ) and deep (DCP) capillary plexuses and choriocapillaris (CC). A segmentation of the AMN lesions using enface OCT images of photoreceptors-retinal pigment epithelium complex was used to discriminate intralesional and extralesional regions on the OCT -A enface slabs of the DCP and CC reconstructions. Each OCT -A slab was imported into ImageJ V.1.50 and digitally binarised for quantitative analyses. RESULTS: Overall, seven patients (mean age 19.4±3.2 years, six women ) affected by AMN were included. The mean best-corrected visual acuity was 0.00±0.00 logarithm of the minimum angle of resolution. Twelve healthy age-matched subjects (mean age 22±3.4 years, 10 women ) represented the control group. The quantitative analysis of global vessel densities showed that the CC vessel density was significantly lower in patients with AMN (0.495±0.03) compared with the age-matched controls (0.545±0.02) (corrected p=0.0003). The intralesional vessel density of the DCP was 0.349±0.04 in AMN and vs 0.497±0.02 in the controls (corrected p=0.0002). CONCLUSIONS: Our study confirmed inner choroidal vascular flow void as a possible pathogenetic mechanism of AMN . We also found a focal impairment of the DCP within the AMN lesions . Future studies are needed to clarify which is the primary location of the vascular insult in this condition. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Entities: Disease
Gene
Species
Keywords:
acute macular neuroretinopathy; en-face optical coherence tomography; near-infrared reflectance imaging; optical coherence tomography angiography.
Mesh： See more »
Year: 2018
PMID： 29844084 DOI： 10.1136/bjophthalmol-2018-312197
Source DB: PubMed Journal: Br J Ophthalmol ISSN： 0007-1161 Impact factor: 4.638