Literature DB >> 29844041

Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa.

Erik Snesrud1, Rosslyn Maybank1, Yoon I Kwak1, Anthony R Jones1, Mary K Hinkle1, Patrick McGann2.   

Abstract

Whole-genome sequencing (WGS) of historical Pseudomonas aeruginosa clinical isolates identified a chromosomal copy of mcr-5 within a Tn3-like transposon in P. aeruginosa MRSN 12280. The isolate was nonsusceptible to colistin by broth microdilution, and genome analysis revealed no mutations known to confer colistin resistance. To the best of our knowledge, this is the first report of mcr in colistin-nonsusceptible P. aeruginosa.

Entities:  

Keywords:  Pseudomonas aeruginosa; colistin; mcr-5

Mesh：

Substances：

Year:  2018        PMID： 29844041      PMCID： PMC6105811          DOI： 10.1128/AAC.00679-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

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