Literature DB >> 2984024

L-AMP-PCP, an ATP receptor agonist in guinea-pig bladder, is inactive on taenia coli.

S M Hourani, L A Welford, N J Cusack.   

Abstract

L-Adenyl 5'-(beta, gamma-methylene)-diphosphonate (L-AMP-PCP), a potent ATP receptor agonist in the guinea-pig bladder, was tested on the guinea-pig taenia coli. L-AMP-PCP, unlike ATP, did not relax the taenia coli, and it neither enhanced nor inhibited the action of ATP. Unlike ATP, L-AMP-PCP was not degraded by ectonucleotidases on the taenia coli. The lack of pharmacological effect of L-AMP-PCP on the taenia coli supports the suggestion that the ATP receptors here differ from those in the guinea-pig bladder.

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Year:  1985        PMID： 2984024     DOI： 10.1016/0014-2999(85)90726-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

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Authors:  J Nicholls; S M Hourani; I Kitchen
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

Review 2.  Non-adrenergic, non-cholinergic control of the urinary bladder.

Authors:  C H Hoyle
Journal:  World J Urol       Date:  1994       Impact factor: 4.226

Review 3.  Extracellular ATP: effects, sources and fate.

Authors:  J L Gordon
Journal:  Biochem J       Date:  1986-01-15       Impact factor: 3.857

Review 4.  Nomenclature and classification of purinoceptors.

Authors:  B B Fredholm; M P Abbracchio; G Burnstock; J W Daly; T K Harden; K A Jacobson; P Leff; M Williams
Journal:  Pharmacol Rev       Date:  1994-06       Impact factor: 25.468

5.  High- and low-affinity binding sites for [3H]-alpha, beta-methylene ATP in rat urinary bladder membranes.

Authors:  X N Bo; G Burnstock
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

6.  A study of the purinoceptors mediating contraction in the rat colon.

Authors:  S J Bailey; S M Hourani
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

7.  Absence of P2-purinoceptors in hippocampal pathways.

Authors:  T W Stone; N J Cusack
Journal:  Br J Pharmacol       Date:  1989-06       Impact factor: 8.739

8.  Direct effects of adenylyl 5'-(beta,gamma-methylene)diphosphonate, a stable ATP analogue, on relaxant P1-purinoceptors in smooth muscle.

Authors:  S M Hourani; S J Bailey; J Nicholls; I Kitchen
Journal:  Br J Pharmacol       Date:  1991-11       Impact factor: 8.739

9.  Vasoconstrictor responses to the P2x-purinoceptor agonist beta, gamma-methylene-L-ATP in human cutaneous and renal blood vessels.

Authors:  I von Kügelgen; B Krumme; U Schaible; P J Schollmeyer; L C Rump
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

10.  Pharmacological effects of isopolar phosphonate analogues of ATP on P2-purinoceptors in guinea-pig taenia coli and urinary bladder.

Authors:  N J Cusack; S M Hourani; G D Loizou; L A Welford
Journal:  Br J Pharmacol       Date:  1987-04       Impact factor: 8.739
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