Literature DB >> 2984023

Effect of urapidil on beta-adrenoceptors of rat atria.

A J Verberne, M J Rand.   

Abstract

The effects of the antihypertensive drug urapidil were studied on chronotropic responses to isoprenaline in rat isolated atria. Urapidil (1-30 microM) antagonized the responses to isoprenaline competitively, and the pA2 value was 6.05. Thus, in addition to its alpha 1-adrenoceptor blocking action for which the pA2 value is about 7, urapidil has beta-adrenoceptor blocking activity.

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Year:  1985        PMID： 2984023     DOI： 10.1016/0014-2999(85)90725-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

1.  Platelet in vitro responses to urapidil and prazosin.

Authors:  C C Smith; D J Betteridge; B N Prichard
Journal:  Drugs       Date:  1990       Impact factor: 9.546

2.  The effect of urapidil on responses to phenylephrine, angiotensin and isoprenaline in man.

Authors:  B Tomlinson; J C Renondin; B R Graham; B N Prichard
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

Review 3.  Human pharmacology of urapidil.

Authors:  A M Shepherd
Journal:  Drugs       Date:  1988       Impact factor: 9.546

4.  Effect of urapidil on the performance of ischemic myocardium in anesthetized dogs.

Authors:  H Schad; W Heimisch; A Barankay; S Hesse; N Mendler
Journal:  Basic Res Cardiol       Date:  1990 May-Jun       Impact factor: 17.165

Review 5.  Urapidil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of hypertension.

Authors:  H D Langtry; G J Mammen; E M Sorkin
Journal:  Drugs       Date:  1989-12       Impact factor: 9.546
  5 in total

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