Literature DB >> 2983896

Evidence for an association between calmodulin and membrane patches containing gonadotropin-releasing hormone--receptor complexes in cultured gonadotropes.

L Jennes, D Bronson, W E Stumpf, P M Conn.   

Abstract

participation of calmodulin, clathrin, and actin in receptor mediated endocytosis of gonadotropin-releasing hormone (GnRH) was studied in an in vitro system of dispersed pituitary cells with a triple staining procedure. Cells were incubated in D-Lys6-Pro9-Des10-GnRH-biotin and stained with avidin-peroxidase-diaminobenzidine. Calmodulin, clathrin, and actin as well as luteinizing hormone were identified by indirect immunofluorescence with FITC- and rhodamine-labeled second antibody. The results indicate a close spatial association of calmodulin, but not of clathrin and actin, with GnRH-containing plasma membrane patches.

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Year:  1985        PMID： 2983896     DOI： 10.1007/bf00218009

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN： 0302-766X            Impact factor:   5.249


  37 in total

1.  Ca2+-dependent regulator. Production and characterization of a monospecific antibody.

Authors:  J R Dedman; M J Welsh; A R Means
Journal:  J Biol Chem       Date:  1978-10-25       Impact factor: 5.157

Review 2.  Regulation of gonadotropin release, GnRH receptors, and gonadotrope responsiveness: a role for GnRH receptor microaggregation.

Authors:  P M Conn; D C Rogers; S G Seay; H Jinnah; M Bates; D Luscher
Journal:  J Cell Biochem       Date:  1985       Impact factor: 4.429

3.  Receptor-mediated binding and uptake of GnRH agonist and antagonist by pituitary cells.

Authors:  L Jennes; W E Stumpf; P M Conn
Journal:  Peptides       Date:  1984       Impact factor: 3.750

4.  Journey to the center of the cell: role of the receptosome.

Authors:  I H Pastan; M C Willingham
Journal:  Science       Date:  1981-10-30       Impact factor: 47.728

5.  Binding and internalization of a luteinizing hormone-releasing hormone agonist by rat gonadotrophic cells. A radioautographic study.

Authors:  G Pelletier; D Dubé; J Guy; C Séguin; F A Lefebvre
Journal:  Endocrinology       Date:  1982-10       Impact factor: 4.736

6.  Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins.

Authors:  R Montesano; J Roth; A Robert; L Orci
Journal:  Nature       Date:  1982-04-15       Impact factor: 49.962

7.  Ultrastructural immunocytochemical localization of clathrin in cultured fibroblasts.

Authors:  M C Willingham; J H Keen; I H Pastan
Journal:  Exp Cell Res       Date:  1981-04       Impact factor: 3.905

Review 8.  Calmodulin plays a pivotal role in cellular regulation.

Authors:  W Y Cheung
Journal:  Science       Date:  1980-01-04       Impact factor: 47.728

9.  Stimulation of pituitary gonadotropin release does not require internalization of gonadotropin-releasing hormone.

Authors:  P M Conn; R G Smith; D C Rogers
Journal:  J Biol Chem       Date:  1981-02-10       Impact factor: 5.157

10.  Capping of cholera toxin-ganglioside GM1 complexes on mouse lymphocytes is accompanied by co-capping of alpha-actinin.

Authors:  S Kellie; B Patel; E J Pierce; D R Critchley
Journal:  J Cell Biol       Date:  1983-08       Impact factor: 10.539
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  1 in total

1.  Gonadotropin-releasing hormone receptor concentration differentially regulates intracellular signaling pathways in GGH3 cells.

Authors:  J H Pinter; J A Janovick; P M Conn
Journal:  Pituitary       Date:  1999-11       Impact factor: 4.107
  1 in total

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