Literature DB >> 2983625

Serum alpha interferon and lymphocyte inclusions in systemic lupus erythematosus.

J H Klippel, S Carette, O T Preble, R M Friedman, P M Grimley.   

Abstract

The relationship between serum acid-labile alpha interferon and tubuloreticular inclusions within the cytoplasm of circulating lymphocytes was studied in 46 patients with systemic lupus erythematosus. Elevated levels of interferon (greater than or equal to 8 IU/ml) were found in 17 patients and lymphocyte inclusions in 35. The mean serum interferon concentration in patients with lymphocyte inclusions was significantly higher than in patients without inclusions (17.2 versus 2.4 IU/ml, p less than 0.01). Inclusions were found in 16 of 17 patients with elevated interferon and also in 19 of 29 patients without interferon (p = 0.026). In lupus, serum interferon appears to be a sufficient though not an essential marker for the presence of lymphocyte inclusions.

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Year:  1985        PMID： 2983625      PMCID： PMC1001582          DOI： 10.1136/ard.44.2.104

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  31 in total

1.  Tubular aggregates in endoplasmic reticulum: evidence against their viral nature.

Authors:  J R Baringer; P Swoveland
Journal:  J Ultrastruct Res       Date:  1972-11

2.  Virus-like structure in Sjögren's syndrome.

Authors:  M A Shearn; W H Tu; B G Stephens; J C Lee
Journal:  Lancet       Date:  1970-03-14       Impact factor: 79.321

3.  Intracellular branched tubular structures in osteosarcoma. An ultrastructural and serological study.

Authors:  A B Jensen; H J Spjut; M N Smith; F Rapp
Journal:  Cancer       Date:  1971-06       Impact factor: 6.860

4.  Abnormal structures in circulating lymphocytes from patients with systemic lupus erythematosus and related diseases.

Authors:  P M Grrimley; J L Decker; H J Michelitch; M M Frantz
Journal:  Arthritis Rheum       Date:  1973 May-Jun

5.  Tubular aggregates in endoplasmic reticulum in herpes-simplex encephalitis.

Authors:  J R Baringer
Journal:  N Engl J Med       Date:  1971-10-21       Impact factor: 91.245

6.  Endothelial inclusions in dermatomyositis.

Authors:  W L Norton; E Velayos; L Robison
Journal:  Ann Rheum Dis       Date:  1970-01       Impact factor: 19.103

7.  Cytoplasmic tubular structures in kidney biopsies in systemic lupus erythematosus.

Authors:  E R Hurd; E Eigenbrodt; M Ziff; S W Strunk
Journal:  Arthritis Rheum       Date:  1969-10

8.  Interferon-related leukocyte inclusions in acquired immune deficiency syndrome: localization in T cells.

Authors:  P M Grimley; Y H Kang; W Frederick; A H Rook; M Kostianovsky; J A Sonnabend; A M Macher; G V Quinnan; R M Friedman; H Masur
Journal:  Am J Clin Pathol       Date:  1984-02       Impact factor: 2.493

9.  Glomerular microtubules of systemic lupus erythematosus.

Authors:  T Pincus; N R Blacklow; P M Grimley; J A Bellanti
Journal:  Lancet       Date:  1970-11-21       Impact factor: 79.321

10.  Virus-like structures in lupus erythematosus.

Authors:  K Kawano; L Miller; P Kimmelstiel
Journal:  N Engl J Med       Date:  1969-11-27       Impact factor: 91.245
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  5 in total

1.  Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-alpha (IFN-alpha) production acting on leucocytes resembling immature dendritic cells.

Authors:  H Vallin; S Blomberg; G V Alm; B Cederblad; L Rönnblom
Journal:  Clin Exp Immunol       Date:  1999-01       Impact factor: 4.330

2.  Lupus-like glomerulonephritis: an autoimmune complication of hepatitis C infection.

Authors:  Liliane Hobeika; Monica Srivastava; Mai Vo; Marie D Philipneri; David S Brink; Nadia Wasi; Krista L Lentine
Journal:  CEN Case Rep       Date:  2012-03-27

3.  Expression of interferon-alpha receptor mRNA in the liver in chronic liver diseases associated with hepatitis C virus: relation to effectiveness of interferon therapy.

Authors:  R Fukuda; N Ishimura; S Ishihara; A Tokuda; S Satoh; S Sakai; S Akagi; M Watanabe; S Fukumoto
Journal:  J Gastroenterol       Date:  1996-12       Impact factor: 7.527

Review 4.  Emerging therapies for systemic lupus erythematosus--focus on targeting interferon-alpha.

Authors:  Eben I Lichtman; Simon M Helfgott; Martin A Kriegel
Journal:  Clin Immunol       Date:  2012-04-06       Impact factor: 3.969

Review 5.  Type I interferon dysregulation and neurological disease.

Authors:  Sarah McGlasson; Alexa Jury; Andrew Jackson; David Hunt
Journal:  Nat Rev Neurol       Date:  2015-08-25       Impact factor: 42.937
  5 in total

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