Literature DB >> 2983267

Blockade of intrathecal 5-hydroxytryptamine-induced antinociception in rats by noradrenaline depletion.

B G Minor, C Post, T Archer.   

Abstract

The analgesic effect of 5-hydroxytryptamine (5-HT, 200 and 250 micrograms/kg) administered into the lumbar intrathecal space of rats was blocked in the tail-flick, hot-plate and shock titration tests of nociception when the animals had previously been treated with N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4), which depletes noradrenaline in the spinal cord. These results suggest an important modulatory role of noradrenaline upon spinal 5-HT mechanisms.

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Year:  1985        PMID： 2983267     DOI： 10.1016/s0304-3940(85)80115-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  4 in total

1.  5-HT agonist induced analgesia modulated by central but not peripheral noradrenaline depletion in rats.

Authors:  B G Minor; T Archer; C Post; G Jonsson; A K Mohammed
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

2.  Effects of dorsal rhizotomy and selective lesion of serotonergic and noradrenergic systems on 5-HT1A, 5-HT1B, and 5-HT3 receptors in the rat spinal cord.

Authors:  A M Laporte; C M Fattaccini; M C Lombard; J Chauveau; M Hamon
Journal:  J Neural Transm Gen Sect       Date:  1995

3.  Intrathecal noradrenaline restores 5-methoxy-N,N-dimethyltryptamine induced antinociception abolished by intrathecal 6-hydroxydopamine.

Authors:  B G Minor; M L Persson; C Post; G Jonsson; T Archer
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

4.  5-Methoxy-N,N-dimethyltryptamine-induced analgesia is blocked by alpha-adrenoceptor antagonists in rats.

Authors:  T Archer; W Danysz; G Jonsson; B G Minor; C Post
Journal:  Br J Pharmacol       Date:  1986-10       Impact factor: 8.739
  4 in total

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