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Literature DB >> 2982827

Regulation of neuroendocrine gene expression by alternative RNA processing. Colocalization of calcitonin and calcitonin gene-related peptide in thyroid C-cells.

M I Sabate, L S Stolarsky, J M Polak, S R Bloom, I M Varndell, M A Ghatei, R M Evans, M G Rosenfeld.

Abstract

The generation of two discrete mRNAs encoding different polypeptide products in expression of the rat calcitonin, CGRP gene provides an example of developmentally determined alternative RNA processing events in the neuroendocrine system. Both mature mRNA transcripts and their peptide products, encoding either calcitonin or calcitonin gene-related peptide (CGRP) are co-produced in identical thyroid C-cells, in a ratio of 95:1, respectively. These data suggest that the generation of the two mRNAs reflect the actions of a factor(s) dictating alternative RNA processing events.

Entities: Gene Species

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Year: 1985 PMID： 2982827

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

22 in total

Review 1. Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis.

Authors: J Zhao; L Hyman; C Moore
Journal: Microbiol Mol Biol Rev Date: 1999-06 Impact factor: 11.056

2. Co-secretion of calcitonin gene-related peptide, gastrin-releasing peptide and ACTH by a carcinoid tumour metastasizing to the cerebellum.

Authors: M A Ghatei; M R Stratton; J M Allen; G F Joplin; J M Polak; S R Bloom
Journal: Postgrad Med J Date: 1987-02 Impact factor: 2.401

3. Hybridohistochemical demonstration of alternative splicing of the CALC-I gene.

Authors: M Denijn; R A De Weger; C J Lips; J A Van Unnik; W Den Otter
Journal: Am J Pathol Date: 1991-02 Impact factor: 4.307

4. Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing.

Authors: Hua-Lin Zhou; Andrew P Baraniak; Hua Lou
Journal: Mol Cell Biol Date: 2006-11-13 Impact factor: 4.272

5. Immunohistochemical study of medullary thyroid carcinoma: relationship of clinical features to prognostic factors in 36 patients.

Authors: H Takami; T Bessho; T Kameya; T Mimura; K Ito; O Abe; Y Hosoda; J Shikata
Journal: World J Surg Date: 1988-08 Impact factor: 3.352

10. Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by both a downstream element within the intron 3' splice acceptor and an element upstream of the P41 initiation site.

Authors: Jianming Qiu; Ramnath Nayak; David J Pintel
Journal: J Virol Date: 2004-01 Impact factor: 5.103

Regulation of neuroendocrine gene expression by alternative RNA processing. Colocalization of calcitonin and calcitonin gene-related peptide in thyroid C-cells.

Review 1. Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis.

2. Co-secretion of calcitonin gene-related peptide, gastrin-releasing peptide and ACTH by a carcinoid tumour metastasizing to the cerebellum.

3. Hybridohistochemical demonstration of alternative splicing of the CALC-I gene.

4. Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing.

5. Immunohistochemical study of medullary thyroid carcinoma: relationship of clinical features to prognostic factors in 36 patients.

Review 6. Peptides from the calcitonin genes: molecular genetics, structure and function.

7. Regulatory peptides in the respiratory tract of Macaca fascicularis.

8. Model for tissue specific Calcitonin/CGRP-I RNA processing from in vitro experiments.

9. Both U2 snRNA and U12 snRNA are required for accurate splicing of exon 5 of the rat calcitonin/CGRP gene.

10. Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by both a downstream element within the intron 3' splice acceptor and an element upstream of the P41 initiation site.