Literature DB >> 2982647

Enhanced expression of Epstein-Barr virus early antigens by antitubulin agents in a latently infected human lymphoblastoid cell line.

J Fujita, O Yoshida, H Tokuda, K Sugawara, Y Ito.   

Abstract

28 anticancer agents have been surveyed for Epstein-Barr virus (EBV) activating potency. Two vinca alkaloids with antitubulin activity, vinblastine (VLB) and vincristine (VCR), enhanced the expression of EBV early antigens (EA) in a latently infected human lymphoblastoid cell line (Raji), when used in combination with n-butyrate. Other antitubulin agents, colchicine, colcemid, and podophyllotoxin, had the same effect, although their effects were less than that of the potent tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA).

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Year:  1985        PMID： 2982647     DOI： 10.1007/bf02004511

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Activation of latent Epstein-Barr virus by antibody to human IgM.

Authors:  M G Tovey; G Lenoir; J Begon-Lours
Journal:  Nature       Date:  1978-11-16       Impact factor: 49.962

2.  Tumor initiators and promoters in the induction of Epstein-Barr virus.

Authors:  H zur Hausen; G W Bornkamm; R Schmidt; E Hecker
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

3.  Immunofluorescent antigen associated with Epstein-Barr virus induced by 5-Iododeoxyuridine.

Authors:  K Sugawara; T Osato
Journal:  Nat New Biol       Date:  1973-11-21

4.  Appearance of cytoskeletal components on the surface of leukemia cells and of lymphocytes transformed by mitogens and Epstein-Barr virus.

Authors:  R J Bachvaroff; F Miller; F T Rapaport
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

5.  Epstein-Barr virus induction by a serum factor. I. Induction and cooperation with additional inducers.

Authors:  G Bauer; P Höfler; H Zur Hausen
Journal:  Virology       Date:  1982-08       Impact factor: 3.616

6.  Do tumor promoters affect DNA after all?

Authors:  J L Marx
Journal:  Science       Date:  1983-01-14       Impact factor: 47.728

7.  Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners.

Authors:  J D Loike; C F Brewer; H Sternlicht; W J Gensler; S B Horwitz
Journal:  Cancer Res       Date:  1978-09       Impact factor: 12.701

8.  Mutagens, carcinogens, and tumor promoters in our daily food.

Authors:  T Sugimura
Journal:  Cancer       Date:  1982-05-15       Impact factor: 6.860

9.  Activation of the EBV-cycle and aggregation of human blood lymphocytes by the tumor promoters teleocidin, lyngbyatoxin A, aplysiatoxin and debromoaplysiatoxin.

Authors:  L Eliasson; B Kallin; M Patarroyo; G Klein; H Fujiki; T Sugimura
Journal:  Int J Cancer       Date:  1983-01-15       Impact factor: 7.396

10.  A short-term in vitro assay for promoter substances using human lymphoblastoid cells latently infected with Epstein-Barr virus.

Authors:  Y Ito; S Yanase; J Fujita; T Harayama; M Takashima; H Imanaka
Journal:  Cancer Lett       Date:  1981-06       Impact factor: 8.679
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