Literature DB >> 2982635

Hippocampal slices of kindled rats reveal calcium involvement in epileptogenesis.

W J Wadman, U Heinemann, A Konnerth, S Neuhaus.   

Abstract

Daily repeated tetanic electrical stimulation (kindling) of the brain may cause a long term enhancement of synaptic transmission and epileptiform activity of progressive severity and generalisation, eventually leading to spontaneous seizures. Evidence for a cellular mechanism underlying kindling has been obtained in vitro in slices from the hippocampus of kindled rats. A marked enhancement in extracellular calcium changes, induced by electrical stimulation or by iontophoresis of excitatory aminoacids was found in kindled tissue. This implies that changes in dendritic calcium conductances are involved in kindling epileptogenesis.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2982635     DOI： 10.1007/bf00236547

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  22 in total

Review 1.  Kindling: the first decade.

Authors:  R Racine
Journal:  Neurosurgery       Date:  1978 Sep-Oct       Impact factor: 4.654

2.  Undershoots following stimulus-induced rises of extracellular potassium concentration in cerebral cortex of cat.

Authors:  U Heinemann; H D Lux
Journal:  Brain Res       Date:  1975-07-25       Impact factor: 3.252

3.  Hypothesis regarding the cellular mechanisms responsible for long-term synaptic potentiation in the hippocampus.

Authors:  M Baudry; G Lynch
Journal:  Exp Neurol       Date:  1980-04       Impact factor: 5.330

4.  Modification of seizure activity by electrical stimulation. II. Motor seizure.

Authors:  R J Racine
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1972-03

Review 5.  The kindling model of epilepsy: a review.

Authors:  J O McNamara; M C Byrne; R M Dasheiff; J G Fitz
Journal:  Prog Neurobiol       Date:  1980       Impact factor: 11.685

6.  Two types of interictal transients of reversed polarity in rat hippocampus during kindling.

Authors:  W J Wadman; F H Da Silva; L W Leung
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1983-03

7.  Extracellular calcium and potassium changes in hippocampal slices.

Authors:  C Benninger; J Kadis; D A Prince
Journal:  Brain Res       Date:  1980-04-07       Impact factor: 3.252

8.  Kindling induces long-lasting alterations in response of hippocampal neurons to elevated potassium levels in vitro.

Authors:  A P Oliver; B J Hoffer; R J Wyatt
Journal:  Science       Date:  1980-06-13       Impact factor: 47.728

9.  A permanent change in brain function resulting from daily electrical stimulation.

Authors:  G V Goddard; D C McIntyre; C K Leech
Journal:  Exp Neurol       Date:  1969-11       Impact factor: 5.330

10.  Orthodromic activation of hippocampal CA1 region of the rat.

Authors:  L W Leung
Journal:  Brain Res       Date:  1979-10-26       Impact factor: 3.252
View more
  9 in total

Review 1.  Calcium and epileptogenesis.

Authors:  U Heinemann; B Hamon
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972

Review 2.  Molecular biology of glycinergic neurotransmission.

Authors:  F Zafra; C Aragón; C Giménez
Journal:  Mol Neurobiol       Date:  1997-06       Impact factor: 5.590

3.  Unilateral up-regulation of glutamate receptors in limbic regions of amygdaloid-kindled rats.

Authors:  M Cincotta; N A Young; P M Beart
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

4.  Effects of GABA and bicuculline on N-methyl-D-aspartate- and quisqualate-induced reductions in extracellular free calcium in area CA1 of the hippocampal slice.

Authors:  B Hamon; U Heinemann
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972

5.  Decrease in GABA immunoreactivity and alteration of GABA metabolism after kindling in the rat hippocampus.

Authors:  W Kamphuis; E Huisman; W J Wadman; F H Lopes da Silva
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

6.  Adenosine antagonists combined with 4-aminopyridine cause partial recovery of synaptic transmission in low Ca media.

Authors:  P Schubert; U Heinemann
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

7.  Regulation of Physical Microglia-Neuron Interactions by Fractalkine Signaling after Status Epilepticus.

Authors:  Ukpong B Eyo; Jiyun Peng; Madhuvika Murugan; Mingshu Mo; Almin Lalani; Ping Xie; Pingyi Xu; David J Margolis; Long-Jun Wu
Journal:  eNeuro       Date:  2017-01-16

Review 8.  Migraine Aura, Transient Ischemic Attacks, Stroke, and Dying of the Brain Share the Same Key Pathophysiological Process in Neurons Driven by Gibbs-Donnan Forces, Namely Spreading Depolarization.

Authors:  Coline L Lemale; Janos Lückl; Viktor Horst; Clemens Reiffurth; Sebastian Major; Nils Hecht; Johannes Woitzik; Jens P Dreier
Journal:  Front Cell Neurosci       Date:  2022-02-10       Impact factor: 6.147

9.  Ganglioside changes associated with temporal lobe epilepsy in the human hippocampus.

Authors:  R K Yu; J A Holley; L J Macala; D D Spencer
Journal:  Yale J Biol Med       Date:  1987 Mar-Apr
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.