Literature DB >> 2982629

Mitogenesis induced by calcium-containing crystals. Role of intracellular dissolution.

H S Cheung, D J McCarty.   

Abstract

Hydroxyapatite, like other calcium-containing crystals previously studied by us, is mitogenic for cultured human fibroblasts. This mitogenic effect is not a result of increased ambient calcium concentration due to extracellular crystal dissolution. Synthetic crystals labelled uniformly with calcium 45 (45Ca) undergo endocytosis when incubated with cells and are solubilized. Such solubilization is inhibited by chloroquine or ammonium chloride in concentrations that significantly block the mitogenic effect of crystals but not that of serum. The data suggest that mitogenesis and intracellular crystal dissolution are related phenomena.

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Year:  1985        PMID： 2982629     DOI： 10.1016/0014-4827(85)90152-1

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  14 in total

Review 1.  Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications.

Authors:  Noam Eliaz; Noah Metoki
Journal:  Materials (Basel)       Date:  2017-03-24       Impact factor: 3.623

2.  Osteoblast responses to as-deposited and heat treated sputtered CaP surfaces.

Authors:  J L Ong; D R Villarreal; R Cavin; K Ma
Journal:  J Mater Sci Mater Med       Date:  2001-06       Impact factor: 3.896

3.  In vitro bioactivity of sol-gel-derived hydroxyapatite particulate nanofiber modified titanium.

Authors:  Madhab Prasad Bajgai; Daman Chandra Parajuli; Soo-Jin Park; Kong Hee Chu; Hyung-Sub Kang; Hak Yong Kim
Journal:  J Mater Sci Mater Med       Date:  2009-10-23       Impact factor: 3.896

Review 4.  Milwaukee shoulder syndrome.

Authors:  D J McCarty
Journal:  Trans Am Clin Climatol Assoc       Date:  1991

Review 5.  Calcium, cyclic AMP and protein kinase C--partners in mitogenesis.

Authors:  J F Whitfield; J P Durkin; D J Franks; L P Kleine; L Raptis; R H Rixon; M Sikorska; P R Walker
Journal:  Cancer Metastasis Rev       Date:  1987       Impact factor: 9.264

6.  Chemical changes in hydroxyapatite biomaterial under in vivo and in vitro biological conditions.

Authors:  I Orly; M Gregoire; J Menanteau; M Heughebaert; B Kerebel
Journal:  Calcif Tissue Int       Date:  1989-07       Impact factor: 4.333

7.  Endocytosis precedes dissolution of basic calcium phosphate crystals by murine macrophages.

Authors:  J L Owens; H S Cheung; D J McCarty
Journal:  Calcif Tissue Int       Date:  1986-03       Impact factor: 4.333

8.  Systemic and local effects of long-term exposure to alkaline drinking water in rats.

Authors:  M E Merne; K J Syrjänen; S M Syrjänen
Journal:  Int J Exp Pathol       Date:  2001-08       Impact factor: 1.925

Review 9.  Calcium pyrophosphate dihydrate and basic calcium phosphate crystal-induced arthropathies: update on pathogenesis, clinical features, and therapy.

Authors:  Hang-Korng Ea; Frédéric Lioté
Journal:  Curr Rheumatol Rep       Date:  2004-06       Impact factor: 4.592

Review 10.  Hydroxyapatite deposition disease of the joint.

Authors:  Eamonn S Molloy; Geraldine M McCarthy
Journal:  Curr Rheumatol Rep       Date:  2003-06       Impact factor: 4.592
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