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Literature DB >> 2982479

Hydrogen peroxide and hydroxyl free radical production by hematoporphyrin derivative, ascorbate and light.

Abstract

Photofrin II, a commercial preparation of a hematoporphyrin derivative containing a high proportion of the active di-hematoporphyrin ether, was found to convert oxygen to hydrogen peroxide and hydroxyl free radicals in the presence of ascorbate and light. In addition, a light-dependent increase in the ascorbate free radical concentration was observed in hematoporphyrin derivative/ascorbate solutions with subsequent oxidation of ascorbate.

Entities: Chemical

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Year: 1985 PMID： 2982479 DOI： 10.1016/s0304-3835(15)30009-4

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

7 in total

1. Ascorbate enhances the toxicity of the photodynamic action of Verteporfin in HL-60 cells.

Authors: Galina G Kramarenko; Werner W Wilke; Disha Dayal; Garry R Buettner; Freya Q Schafer
Journal: Free Radic Biol Med Date: 2006-01-19 Impact factor: 7.376

2. Ascorbate reacts with singlet oxygen to produce hydrogen peroxide.

Authors: Galina G Kramarenko; Stephen G Hummel; Sean M Martin; Garry R Buettner
Journal: Photochem Photobiol Date: 2006 Nov-Dec Impact factor: 3.421

3. Lipid peroxidation in erythrocyte membranes: cholesterol product analysis in photosensitized and xanthine oxidase-catalyzed reactions.

Authors: A W Girotti; G J Bachowski; J E Jordan
Journal: Lipids Date: 1987-06 Impact factor: 1.880

4. Concentration dependence of vitamin C in combinations with vitamin E and zeaxanthin on light-induced toxicity to retinal pigment epithelial cells.

Authors: Małgorzata Różanowska; Linda Bakker; Michael E Boulton; Bartosz Różanowski
Journal: Photochem Photobiol Date: 2012-10-01 Impact factor: 3.421

Hydrogen peroxide and hydroxyl free radical production by hematoporphyrin derivative, ascorbate and light.

1. Ascorbate enhances the toxicity of the photodynamic action of Verteporfin in HL-60 cells.

2. Ascorbate reacts with singlet oxygen to produce hydrogen peroxide.

3. Lipid peroxidation in erythrocyte membranes: cholesterol product analysis in photosensitized and xanthine oxidase-catalyzed reactions.

4. Concentration dependence of vitamin C in combinations with vitamin E and zeaxanthin on light-induced toxicity to retinal pigment epithelial cells.

5. Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation.

Review 6. Current status of photodynamic therapy in oncology.

7. Catalytic therapy of cancer with ascorbate and extracts of medicinal herbs.