Literature DB >> 2982362

Purification of the cardiac 1,4-dihydropyridine receptor/calcium channel complex.

A Rengasamy, J Ptasienski, M M Hosey.   

Abstract

Chick heart membranes were labelled with [3H]PN 200-110, a 1,4-dihydropyridine calcium channel antagonist. The [3H]PN 200-110 receptors were solubilized with digitonin and purified 600-fold using several chromatographic systems and sucrose density gradient centrifugation. Analyses by gel electrophoresis revealed that the final product was enriched in two peptides with molecular weights of 60,000 and 54,000, and another of 34,000.

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Year:  1985        PMID： 2982362     DOI： 10.1016/0006-291x(85)90563-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Photoaffinity labelling of the cardiac calcium channel. (-)-[3H]azidopine labels a 165 kDa polypeptide, and evidence against a [3H]-1,4-dihydropyridine-isothiocyanate being a calcium-channel-specific affinity ligand.

Authors:  D R Ferry; A Goll; H Glossmann
Journal:  Biochem J       Date:  1987-04-01       Impact factor: 3.857

2.  Subcellular distribution and isolation of the Ca2+ antagonist receptor associated with the voltage regulated Ca2+ channel from rabbit heart muscle.

Authors:  B S Tuana; B J Murphy; Q Yi
Journal:  Mol Cell Biochem       Date:  1987-08       Impact factor: 3.396

3.  Purification and affinity labeling of dihydropyridine receptor from rabbit skeletal muscle membranes.

Authors:  U Kanngiesser; P Nalik; O Pongs
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

Review 4.  Calcium channels: molecular pharmacology, structure and regulation.

Authors:  M M Hosey; M Lazdunski
Journal:  J Membr Biol       Date:  1988-09       Impact factor: 1.843

5.  Novel interactions of cations with dihydropyridine calcium antagonist binding sites in brain.

Authors:  G T Bolger; P Skolnick
Journal:  Br J Pharmacol       Date:  1986-08       Impact factor: 8.739

6.  N-myc gene product expression in neuroblastoma.

Authors:  H Hashimoto; Y Daimaru; M Enjoji; A Nakagawara
Journal:  J Clin Pathol       Date:  1989-01       Impact factor: 3.411

7.  Relationship between beta-adrenoceptors and calcium channels in human ventricular myocardium.

Authors:  D R Ferry; A J Kaumann
Journal:  Br J Pharmacol       Date:  1987-03       Impact factor: 8.739

8.  Effect of thyroid hormone on slow calcium channel function in cultured chick ventricular cells.

Authors:  D Kim; T W Smith; J D Marsh
Journal:  J Clin Invest       Date:  1987-07       Impact factor: 14.808
  8 in total

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