Literature DB >> 2981751

Administration of silica prevents diabetes in BB-rats.

U Oschilewski, U Kiesel, H Kolb.   

Abstract

Administration of silica to young BB-rats almost completely prevented the development of spontaneous diabetes. Only 1 of 31 silica-treated rats developed hyperglycemia, whereas 9 of 31 in the untreated group did so. Since silica is highly specific in its action against macrophages, our observations indicate an important role of these cells in the pathogenesis of the disease.

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Year:  1985        PMID： 2981751     DOI： 10.2337/diab.34.2.197

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  41 in total

1.  Low incidence of autoimmune type I diabetes in BB rats fed a hydrolysed casein-based diet associated with early inhibition of non-macrophage-dependent hyperexpression of MHC class I molecules on beta cells.

Authors:  X B Li; F W Scott; Y H Park; J W Yoon
Journal:  Diabetologia       Date:  1995-10       Impact factor: 10.122

2.  In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.

Authors:  Boris Calderon; Anish Suri; Emil R Unanue
Journal:  Am J Pathol       Date:  2006-12       Impact factor: 4.307

Review 3.  Do post-translational beta cell protein modifications trigger type 1 diabetes?

Authors:  Joachim Størling; Anne Julie Overgaard; Caroline Anna Brorsson; Francesco Piva; Claus Heiner Bang-Berthelsen; Claus Haase; Jørn Nerup; Flemming Pociot
Journal:  Diabetologia       Date:  2013-09-19       Impact factor: 10.122

Review 4.  The role of interleukin-1 in the pathogenesis of IDDM.

Authors:  T Mandrup-Poulsen
Journal:  Diabetologia       Date:  1996-09       Impact factor: 10.122

5.  Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages.

Authors:  T J Wilkin
Journal:  Diabetologia       Date:  1988-10       Impact factor: 10.122

6.  Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM.

Authors:  M J Hussain; M Peakman; H Gallati; S S Lo; M Hawa; G C Viberti; P J Watkins; R D Leslie; D Vergani
Journal:  Diabetologia       Date:  1996-01       Impact factor: 10.122

7.  A longitudinal ultrastructural study of pancreatic cellular damage in murine streptozotocin diabetes.

Authors:  E R Richens; F M Tungekar; K Behbehani
Journal:  Acta Diabetol Lat       Date:  1988 Jul-Sep

8.  High stimulatory activity of dendritic cells from diabetes-prone BioBreeding/Worcester rats exposed to macrophage-derived factors.

Authors:  A Tafuri; W E Bowers; E S Handler; M Appel; R Lew; D Greiner; J P Mordes; A A Rossini
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

9.  The activation of the arginine-citrulline cycle in macrophages from the spontaneously diabetic BB rat.

Authors:  G Wu; N E Flynn
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857

10.  Circulating monocytes are activated in newly diagnosed type 1 diabetes mellitus patients.

Authors:  K Josefsen; H Nielsen; S Lorentzen; P Damsbo; K Buschard
Journal:  Clin Exp Immunol       Date:  1994-12       Impact factor: 4.330
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