Literature DB >> 2981714

Subcellular localization and some properties of the enzymes hydrolysing inositol polyphosphates in rat liver.

S K Joseph, R J Williams.   

Abstract

The hydrolysis of inositol [32P]trisphosphate (IP3) and inositol [32P]bisphosphate (IP2) has been examined in subcellular fractions of rat liver. IP3 was degraded by an enzyme located in the plasma membrane which did not degrade IP2. Cytosolic fractions were found to degrade both IP2 and IP3. The IP3 phosphatase activity of liver plasma membranes displayed a neutral pH optimum, was Mg2+ dependent and was not inhibited by high concentrations of Li+. Half-maximal activity of the enzymes hydrolysing IP3 and IP2 was obtained with substrate concentrations in the range 1-2 microM. The significance of these observations to the proposed Ca2+-mobilizing role of IP3 is discussed.

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Year:  1985        PMID： 2981714     DOI： 10.1016/0014-5793(85)81061-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

1.  The dephosphorylation pathway of D-myo-inositol 1,3,4,5-tetrakisphosphate in rat brain.

Authors:  C Erneux; A Delvaux; C Moreau; J E Dumont
Journal:  Biochem J       Date:  1987-11-01       Impact factor: 3.857

2.  Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.

Authors:  S B Shears; J B Parry; E K Tang; R F Irvine; R H Michell; C J Kirk
Journal:  Biochem J       Date:  1987-08-15       Impact factor: 3.857

3.  Preferential localization of rat liver D-myo-inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase in bile-canalicular plasma membrane and 'late' endosomal vesicles.

Authors:  S B Shears; W H Evans; C J Kirk; R H Michell
Journal:  Biochem J       Date:  1988-12-01       Impact factor: 3.857

Review 4.  Metabolism of the inositol phosphates produced upon receptor activation.

Authors:  S B Shears
Journal:  Biochem J       Date:  1989-06-01       Impact factor: 3.857

5.  Fluoroaluminates mimic guanosine 5'-[gamma-thio]triphosphate in activating the polyphosphoinositide phosphodiesterase of hepatocyte membranes. Role for the guanine nucleotide regulatory protein Gp in signal transduction.

Authors:  S Cockcroft; J A Taylor
Journal:  Biochem J       Date:  1987-01-15       Impact factor: 3.857

6.  D-myo-inositol 1,4,5-trisphosphate phosphatase in skeletal muscle.

Authors:  D Milani; P Volpe; T Pozzan
Journal:  Biochem J       Date:  1988-09-01       Impact factor: 3.857

Review 7.  The inositol phospholipids: a stereochemical view of biological activity.

Authors:  R Parthasarathy; F Eisenberg
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

8.  Two components of hormone-evoked calcium release from intracellular stores of pancreatic acinar cells.

Authors:  S Muallem; S J Pandol; T G Beeker
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

9.  Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-triphosphate.

Authors:  S B Shears; D J Storey; A J Morris; A B Cubitt; J B Parry; R H Michell; C J Kirk
Journal:  Biochem J       Date:  1987-03-01       Impact factor: 3.857

10.  Influence of Mg2+ and pH on n.m.r. spectra and radioligand binding of inositol 1,4,5-trisphosphate.

Authors:  A M White; M A Varney; S P Watson; S Rigby; C S Liu; J G Ward; C B Reese; H C Graham; R J Williams
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857
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