Literature DB >> 2981366

Presence of markers for virulence in the unique short region or repeat region or both of pseudorabies hybrid viruses.

A Berns, A van den Ouweland, W Quint, J van Oirschot, A Gielkens.   

Abstract

The unique short region and part of the repeat region of virulent pseudorabies virus strain NIA-3 was replaced by the corresponding region of the avirulent NIA-4 strain by transfection with subgenomic DNA fragments. The resulting hybrid virus showed a reduced virulence in both mice and pigs. Therefore, important markers for virulence are located in the unique short or repeat region or both of pseudorabies virus. We provide evidence that the terminally located repeat is not required for the generation of progeny with intact pseudorabies virus genomes. Apparently, the terminal repeat is regenerated from the internal repeat.

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Year:  1985        PMID： 2981366      PMCID： PMC254982     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

1.  Structural evolution of the DNA of pseudorabies-defective viral particles.

Authors:  F J Rixon; T Ben-Porat
Journal:  Virology       Date:  1979-08       Impact factor: 3.616

2.  On the structure, functional equivalence, and replication of the four arrangements of herpes simplex virus DNA.

Authors:  B Roizman; R J Jacob; D M Knipe; L S Morse; W T Ruyechan
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1979

3.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

4.  Some characteristics of four attenuated vaccine virus strains and a virulent strain of Aujeszky's disease virus.

Authors:  J T van Oirschot; A L Gielkens
Journal:  Vet Q       Date:  1984-09       Impact factor: 3.320

5.  Intranasal vaccination of pigs against Aujeszky's disease. 1. Comparison of intranasal and parenteral vaccination with an attenuated vaccine in 12-week-old pigs from immunized dams.

Authors:  P W de Leeuw; J M Wijsmuller; J W Zantinga; M J Tielen
Journal:  Vet Q       Date:  1982-04       Impact factor: 3.320

6.  M-MuLV-induced leukemogenesis: integration and structure of recombinant proviruses in tumors.

Authors:  H van der Putten; W Quint; J van Raaij; E R Maandag; I M Verma; A Berns
Journal:  Cell       Date:  1981-06       Impact factor: 41.582

7.  Equalization of the inverted repeat sequences of the pseudorabies virus genome by intermolecular recombination.

Authors:  T Ben-Porat; A Deatly; R A Veach; M L Blankenship
Journal:  Virology       Date:  1984-01-30       Impact factor: 3.616

8.  Molecular cloning of unintegrated and a portion of integrated moloney murine leukemia viral DNA in bacteriophage lambda.

Authors:  A J Berns; M H Lai; R A Bosselman; M A McKennett; L T Bacheler; H Fan; E C Maandag; H V van der Putten; I M Verma
Journal:  J Virol       Date:  1980-10       Impact factor: 5.103

9.  Differentiation of vaccine strains and field isolates of pseudorabies (Aujeszky's disease) virus: trypsin sensitivity and mouse virulence markers.

Authors:  K B Platt; C J Maré; P N Hinz
Journal:  Arch Virol       Date:  1980       Impact factor: 2.574

10.  Localization of the regions of homology between the genomes of herpes simplex virus, type 1, and pseudorabies virus.

Authors:  T Ben-Porat; R A Veach; S Ihara
Journal:  Virology       Date:  1983-05       Impact factor: 3.616
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  22 in total

1.  Characterization of field isolates of suid herpesvirus 1 (Aujeszky's disease virus) as derivatives of attenuated vaccine strains.

Authors:  L S Christensen; I Medveczky; B S Strandbygaard; Z Pejsak
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

2.  Role of a structural glycoprotein of pseudorabies in virus virulence.

Authors:  T C Mettenleiter; L Zsak; A S Kaplan; T Ben-Porat; B Lomniczi
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

3.  Restriction fragment pattern analysis of genomes from French isolates of suis herpes virus 1 (Aujeszky's disease virus).

Authors:  A Jestin; P Blanchard; A Garbar-Chenon; P Vannier; J C Nicolas
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

4.  Comparison by restriction fragment pattern analysis and molecular characterization of some European isolates of Suid herpesvirus 1: a contribution to strain differentiation of European isolates.

Authors:  L S Christensen
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

5.  Role of pseudorabies virus glycoprotein gI in virus release from infected cells.

Authors:  T C Mettenleiter; C Schreurs; F Zuckermann; T Ben-Porat
Journal:  J Virol       Date:  1987-09       Impact factor: 5.103

6.  Host cell-specific growth advantage of pseudorabies virus with a deletion in the genome sequences encoding a structural glycoprotein.

Authors:  T C Mettenleiter; B Lomniczi; N Sugg; C Schreurs; T Ben-Porat
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

7.  Proteins specified by the short unique region of the genome of pseudorabies virus play a role in the release of virions from certain cells.

Authors:  T Ben-Porat; J DeMarchi; J Pendrys; R A Veach; A S Kaplan
Journal:  J Virol       Date:  1986-01       Impact factor: 5.103

8.  Genome location and identification of functions defective in the Bartha vaccine strain of pseudorabies virus.

Authors:  B Lomniczi; S Watanabe; T Ben-Porat; A S Kaplan
Journal:  J Virol       Date:  1987-03       Impact factor: 5.103

9.  Deletions in vaccine strains of pseudorabies virus and their effect on synthesis of glycoprotein gp63.

Authors:  E A Petrovskis; J G Timmins; T M Gierman; L E Post
Journal:  J Virol       Date:  1986-12       Impact factor: 5.103

10.  Complementation analysis of pseudorabies virus gE and gI mutants in retinal ganglion cell neurotropism.

Authors:  L W Enquist; J Dubin; M E Whealy; J P Card
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103
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