Literature DB >> 29809014

Multicomponent Synthesis of Tetrahydroisoquinolines.

Linwei Zeng1, Bo Huang1, Yangyong Shen1, Sunliang Cui1,2.   

Abstract

A multicomponent synthesis of tetrahydroisoquinolines from carboxylic acids, alkynyl ethers, and dihydroisoquinolines is described. This process features readily available starting materials, simple experimental procedures for achievement of molecule complexity, and structural diversity. The preliminary control experiment and crossover reaction provide important insight into the reaction mechanism. The formed tetrahydroisoquinolines could be transformed to an array of compounds.

Entities:  

Year:  2018        PMID： 29809014     DOI： 10.1021/acs.orglett.8b01159

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

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Journal:  RSC Adv       Date:  2022-06-16       Impact factor: 4.036

2.  A catalyst- and solvent-free protocol for the sustainable synthesis of fused 4H-pyran derivatives.

Authors:  Md Musawwer Khan; Sumbulunnisan Shareef; Subash C Sahoo
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4.  Efficient one-pot synthesis and dehydrogenation of tricyclic dihydropyrimidines catalyzed by OMS-2-SO3H, and application of the functional-chromophore products as colorimetric chemosensors.

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5.  Microwave irradiation: a green approach for the synthesis of functionalized N-methyl-1,4-dihydropyridines.

Authors:  M Musawwer Khan; Sarfaraz Khan; Sumbulunnisan Shareef; Subash C Sahoo
Journal:  RSC Adv       Date:  2018-12-14       Impact factor: 4.036

6.  Multicomponent synthesis of dispiroheterocycles using a magnetically separable and reusable heterogeneous catalyst.

Authors:  Yogesh Kumar Tailor; Sarita Khandelwal; Kanchan Verma; Ram Gopal; Mahendra Kumar
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7.  Hercynite silica sulfuric acid: a novel inorganic sulfurous solid acid catalyst for one-pot cascade organic transformations.

Authors:  Masoud Mohammadi; Arash Ghorbani-Choghamarani
Journal:  RSC Adv       Date:  2022-09-13       Impact factor: 4.036

8.  LFZ-4-46, a tetrahydroisoquinoline derivative, induces apoptosis and cell cycle arrest via induction of DNA damage and activation of MAPKs pathway in cancer cells.

Authors:  Lili Xu; Guozheng Huang; Zhihui Zhu; Shasha Tian; Yingying Wei; Huanwu Hong; Xiaowei Lu; Ying Li; Feize Liu; Huajun Zhao
Journal:  Anticancer Drugs       Date:  2021-09-01       Impact factor: 2.248

9.  Multicomponent double Mannich alkylamination involving C(sp2)-H and benzylic C(sp3)-H bonds.

Authors:  Zhencheng Lai; Rongkai Wu; Jiaming Li; Xing Chen; Linwei Zeng; Xi Wang; Jingjing Guo; Zujin Zhao; Hironao Sajiki; Sunliang Cui
Journal:  Nat Commun       Date:  2022-01-21       Impact factor: 14.919
  9 in total

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