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Literature DB >> 29808555

Synthesis of obeticholic acid, a farnesoid X receptor agonist, and its major metabolites labeled with deuterium.

Kuo Gai¹, Yu Huang¹, Baomin Liu¹, Yinsheng Zhang¹.

Abstract

Simple and facile methods for the synthesis of deuterium-labeled obeticholic acid and its 2 metabolites, glycine and taurine conjugates of obeticholic acid, are described herein. The 3 deuterated compounds were applicable for use as internal standards in drug development.

Entities: Chemical

Keywords: deuterium-labeling; internal standards; metabolites; obeticholic acid

Year: 2018 PMID： 29808555 DOI： 10.1002/jlcr.3643

Source DB: PubMed Journal: J Labelled Comp Radiopharm ISSN： 0362-4803 Impact factor: 1.921

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Cited

1 in total

1. Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions.

Authors: Meng-Na Wang; Hai-Tao Yu; Ya-Qian Li; Yun Zeng; Shuang Yang; Guo-Ping Yang; Qi Pei; Jie Huang
Journal: Drug Des Devel Ther Date: 2021-01-14 Impact factor: 4.162

1 in total