Metallothionein in human liver and kidney: relationship to age, sex, diseases and tobacco and alcohol use.

The content of metallothionein (MT) was determined in the livers (MT-L) and the kidneys (MT-K) of 145 deceased persons. The individual values showed marked variations; average levels (arithmetic means +/- S.D.) were 154.9 +/- 151.4 mg/kg liver wet wt. and 160.5 +/- 150.4 mg/kg total kidney wet wt. In contrast to MT-L, MT-K increased with age up to a maximum around mid-life and decreased at higher ages. Neither the MT-L nor the MT-K depend on sex. The MT content significantly correlates with the macroscopic and histopathologic status of the liver. As compared to normal tissue, livers with fatty degeneration, cirrhosis and brown atrophy show MT-L values of 40%, 25% and 233% respectively. Low MT-L of 40% of the control values are also observed in individuals with a history of alcohol abuse. This decline preceded visible macroscopic pathological findings. MT-L also responds to the cause of death. At suicidal overdose of drugs the MT-L is lowered to 62% and at "mechanical" suicides it is increased to 137%. Whereas MT-K is essentially independent of the kidney status, it is significantly increased to approximately 190% in male smokers.