Literature DB >> 29807515

Multi-Target Antitubercular Drugs.

Jessika de Oliveira Viana1, Hamilton Mitsugu Ishiki2, Marcus Tullius Scotti1, Luciana Scotti1,3.   

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this disease. In this context, in this review we report the discovery of 3 classes of compounds that can simultaneously interact with more than one target of Mycobacterium tuberculosis. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Anti tuberculosis drugs; Inhibition; Multi-target drugs; Mycobacterium tuberculosis; Targeting; Tuberculosis.

Mesh:

Substances:

Year:  2018        PMID: 29807515     DOI: 10.2174/1568026618666180528124414

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN: 1568-0266            Impact factor:   3.295


  4 in total

1.  A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis.

Authors:  Michael J Pepi; Shibin Chacko; Gary M Marqus; Vinayak Singh; Zhe Wang; Kyle Planck; Ryan T Cullinane; Penchala N Meka; Deviprasad R Gollapalli; Thomas R Ioerger; Kyu Y Rhee; Gregory D Cuny; Helena I M Boshoff; Lizbeth Hedstrom
Journal:  ACS Infect Dis       Date:  2022-01-11       Impact factor: 5.578

2.  Synthesis, Characterization, and Biological Evaluation of Novel 7-Oxo-7H-thiazolo[3,2-b]-1,2,4-triazine-2-carboxylic Acid Derivatives.

Authors:  Dong Cai; Tai Li; Qian Xie; Xiaofei Yu; Wei Xu; Yu Chen; Zhe Jin; Chun Hu
Journal:  Molecules       Date:  2020-03-13       Impact factor: 4.411

Review 3.  Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis.

Authors:  Giovanni Stelitano; José Camilla Sammartino; Laurent Roberto Chiarelli
Journal:  Molecules       Date:  2020-03-09       Impact factor: 4.411

4.  A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles.

Authors:  Basem Battah; Giulia Chemi; Stefania Butini; Giuseppe Campiani; Simone Brogi; Giovanni Delogu; Sandra Gemma
Journal:  Molecules       Date:  2019-11-29       Impact factor: 4.411

  4 in total

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