Literature DB >> 29807044

Mitochondria in cancer metabolism, an organelle whose time has come?

Rebecca G Anderson1, Lais P Ghiraldeli1, Timothy S Pardee2.   

Abstract

Mitochondria have long been controversial organelles in cancer. Early discoveries in cancer metabolism placed much emphasis on cytosolic contributions. Initial debate focused on if mitochondria had a role in cancer formation and progression at all. More recently the contributions of mitochondria to cancer development and progression have become firmly established. This has led to the identification of novel targets and inhibitors being studied as new therapeutic approaches. This review will summarize the role of mitochondria in cancer and highlight several agents under development.
Copyright © 2018 Elsevier B.V. All rights reserved.

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Year:  2018        PMID： 29807044      PMCID： PMC6420819          DOI： 10.1016/j.bbcan.2018.05.005

Source DB:  PubMed          Journal:  Biochim Biophys Acta Rev Cancer        ISSN： 0304-419X            Impact factor:   10.680


  68 in total

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Journal:  Science       Date:  1956-02-24       Impact factor: 47.728

2.  Mitochondrial dynamics--mitochondrial fission and fusion in human diseases.

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Journal:  N Engl J Med       Date:  2013-12-05       Impact factor: 91.245

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4.  Redox regulation of fos and jun DNA-binding activity in vitro.

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Journal:  Science       Date:  1990-09-07       Impact factor: 47.728

5.  Sensitization of metformin-cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells.

Authors:  Yong Won Choi; In Kyoung Lim
Journal:  Cancer Lett       Date:  2014-01-27       Impact factor: 8.679

6.  Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cells.

Authors:  Jingnan Wang; Karyn Hansen; Robert Edwards; Bennett Van Houten; Wei Qian
Journal:  Biochem Biophys Res Commun       Date:  2014-11-13       Impact factor: 3.575

7.  Metabolic modulation of glioblastoma with dichloroacetate.

Authors:  E D Michelakis; G Sutendra; P Dromparis; L Webster; A Haromy; E Niven; C Maguire; T-L Gammer; J R Mackey; D Fulton; B Abdulkarim; M S McMurtry; K C Petruk
Journal:  Sci Transl Med       Date:  2010-05-12       Impact factor: 17.956

8.  Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.

Authors:  Marko Skrtić; Shrivani Sriskanthadevan; Bozhena Jhas; Marinella Gebbia; Xiaoming Wang; Zezhou Wang; Rose Hurren; Yulia Jitkova; Marcela Gronda; Neil Maclean; Courteney K Lai; Yanina Eberhard; Justyna Bartoszko; Paul Spagnuolo; Angela C Rutledge; Alessandro Datti; Troy Ketela; Jason Moffat; Brian H Robinson; Jessie H Cameron; Jeffery Wrana; Connie J Eaves; Mark D Minden; Jean C Y Wang; John E Dick; Keith Humphries; Corey Nislow; Guri Giaever; Aaron D Schimmer
Journal:  Cancer Cell       Date:  2011-11-15       Impact factor: 31.743

9.  Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim.

Authors:  Hye-Kyung Park; Ji-Eun Lee; Jaehwa Lim; Da-Eun Jo; Soo-Ah Park; Pann-Ghill Suh; Byoung Heon Kang
Journal:  BMC Cancer       Date:  2014-06-13       Impact factor: 4.430

10.  Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport.

Authors:  Juliana Velez; Rongqing Pan; Jason T C Lee; Leonardo Enciso; Marta Suarez; Jorge Eduardo Duque; Daniel Jaramillo; Catalina Lopez; Ludis Morales; William Bornmann; Marina Konopleva; Gerald Krystal; Michael Andreeff; Ismael Samudio
Journal:  Oncotarget       Date:  2016-08-09
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  19 in total

Review 1.  Mitochondrial dynamics and metastasis.

Authors:  Dario C Altieri
Journal:  Cell Mol Life Sci       Date:  2018-11-10       Impact factor: 9.261

Review 2.  PGC-1α participates in tumor chemoresistance by regulating glucose metabolism and mitochondrial function.

Authors:  Yanqing Li; Hu Hei; Songtao Zhang; Wenbo Gong; Yann Liu; Jianwu Qin
Journal:  Mol Cell Biochem       Date:  2022-06-17       Impact factor: 3.396

Review 3.  Targeting mitochondrial metabolism for precision medicine in cancer.

Authors:  Lourdes Sainero-Alcolado; Judit Liaño-Pons; María Victoria Ruiz-Pérez; Marie Arsenian-Henriksson
Journal:  Cell Death Differ       Date:  2022-07-13       Impact factor: 12.067

4.  MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer.

Authors:  Jae Ho Seo; Young Chan Chae; Andrew V Kossenkov; Yu Geon Lee; Hsin-Yao Tang; Ekta Agarwal; Dmitry I Gabrilovich; Lucia R Languino; David W Speicher; Prashanth K Shastrula; Alessandra Maria Storaci; Stefano Ferrero; Gabriella Gaudioso; Manuela Caroli; Davide Tosi; Massimo Giroda; Valentina Vaira; Vito W Rebecca; Meenhard Herlyn; Min Xiao; Dylan Fingerman; Alessandra Martorella; Emmanuel Skordalakes; Dario C Altieri
Journal:  Cancer Res       Date:  2019-10-03       Impact factor: 12.701

5.  Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment.

Authors:  Irene Bertolini; Jagadish C Ghosh; Andrew V Kossenkov; Sudheer Mulugu; Shiv Ram Krishn; Valentina Vaira; Jun Qin; Edward F Plow; Lucia R Languino; Dario C Altieri
Journal:  Dev Cell       Date:  2020-08-10       Impact factor: 12.270

6.  IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α-regulated pseudohypoxic state.

Authors:  Yuan Wang; Ekta Agarwal; Irene Bertolini; Jagadish C Ghosh; Jae Ho Seo; Dario C Altieri
Journal:  FASEB J       Date:  2019-09-17       Impact factor: 5.834

7.  Mitofusin-2 acts as biomarker for predicting poor prognosis in hepatitis B virus related hepatocellular carcinoma.

Authors:  Xiumei Wang; Youde Liu; Jing Sun; Wenjing Gong; Ping Sun; Xiangshuo Kong; Miaomiao Yang; Weiwei Zhang
Journal:  Infect Agent Cancer       Date:  2018-11-26       Impact factor: 2.965

Review 8.  Ferlin Overview: From Membrane to Cancer Biology.

Authors:  Olivier Peulen; Gilles Rademaker; Sandy Anania; Andrei Turtoi; Akeila Bellahcène; Vincent Castronovo
Journal:  Cells       Date:  2019-08-22       Impact factor: 6.600

Review 9.  Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer.

Authors:  Shamir Cassim; Milica Vučetić; Maša Ždralević; Jacques Pouyssegur
Journal:  Cancers (Basel)       Date:  2020-04-30       Impact factor: 6.639

10.  Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer.

Authors:  Jae Ho Seo; Ekta Agarwal; Young Chan Chae; Yu Geon Lee; David S Garlick; Alessandra Maria Storaci; Stefano Ferrero; Gabriella Gaudioso; Umberto Gianelli; Valentina Vaira; Dario C Altieri
Journal:  EBioMedicine       Date:  2019-09-18       Impact factor: 8.143
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