Kageyuki Oba1, Minetaka Maeda1, Gulinu Maimaituxun2, Satoshi Yamaguchi1, Osamu Arasaki1, Daiju Fukuda3, Shusuke Yagi2, Yukina Hirata2, Susumu Nishio2, Takashi Iwase2, Shoichiro Takao4, Kenya Kusunose2, Hirotsugu Yamada2, Takeshi Soeki2, Tetsuzo Wakatsuki2, Masafumi Harada5, Hiroaki Masuzaki6, Masataka Sata2, Michio Shimabukuro1,3,7. 1. Department of Cardiology, Tomishiro Central Hospital. 2. Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School. 3. Department of Cardio-Diabetes Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School. 4. Department of Diagnostic Radiology, Institute of Biomedical Sciences, Tokushima University Graduate School. 5. Department of Radiology, Institute of Biomedical Sciences, Tokushima University Graduate School. 6. Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus. 7. Department of Diabetes, Endocrinology and Metabolism, School of Medicine, Fukushima Medical University.
Abstract
BACKGROUND: Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with atrial fibrillation (AF), it is controversial whether there is a dose-response relationship of increasing EATV along the continuum of AF. We evaluated the effect of the EATV on the prevalence of paroxysmal AF (PAF) and persistent AF (PeAF) and the relationships with cardiac structure and functional remodeling.Methods and Results: Subjects who underwent multidetector computed tomography (MDCT) coronary angiography because of symptoms suggestive of coronary artery disease were divided into sinus rhythm (SR) (n=112), PAF (n=133), and PeAF (n=71) groups. The EATV index (EATV/body surface area, mL/m2) was strongly associated with the prevalence of PAF and PeAF on the model adjusted for known AF risk factors. The effect of the EATV index on the prevalence of PeAF, but not on that of PAF, was modified by the left atrial (LA) dimension, suggesting that extension of the LA dimension is related to EATV expansion in PeAF. The cutoff value of the EATV index for the prevalence was higher in PeAF than in PAF (64 vs. 55 mL/m2, P<0.01). CONCLUSIONS: The EATV index is associated with the prevalence of PAF and PeAF, and its cutoff values are predictive for PAF and PeAF development independently of other AF risk factors.
BACKGROUND: Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with atrial fibrillation (AF), it is controversial whether there is a dose-response relationship of increasing EATV along the continuum of AF. We evaluated the effect of the EATV on the prevalence of paroxysmal AF (PAF) and persistent AF (PeAF) and the relationships with cardiac structure and functional remodeling.Methods and Results: Subjects who underwent multidetector computed tomography (MDCT) coronary angiography because of symptoms suggestive of coronary artery disease were divided into sinus rhythm (SR) (n=112), PAF (n=133), and PeAF (n=71) groups. The EATV index (EATV/body surface area, mL/m2) was strongly associated with the prevalence of PAF and PeAF on the model adjusted for known AF risk factors. The effect of the EATV index on the prevalence of PeAF, but not on that of PAF, was modified by the left atrial (LA) dimension, suggesting that extension of the LA dimension is related to EATV expansion in PeAF. The cutoff value of the EATV index for the prevalence was higher in PeAF than in PAF (64 vs. 55 mL/m2, P<0.01). CONCLUSIONS: The EATV index is associated with the prevalence of PAF and PeAF, and its cutoff values are predictive for PAF and PeAF development independently of other AF risk factors.