Lanting Zhou1, Yanting Feng2, Jingxing Dai2, Jun Ouyang3. 1. Medical College, Hubei University of Arts and Science, Xiangyang Hubei, 441053, P.R.China;Department of Anatomy, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China. 2. Department of Anatomy, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China. 3. Department of Anatomy, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China.jouyang@smu.edu.cn.
Abstract
Objective: To review the research progress of miRNA regulation in the differentiation of adipose-derived stem cells (ADSCs). Methods: The recent literature associated with miRNAs and differentiation of ADSCs was reviewed. The regulatory mechanism was analyzed in detail and summarized. Results: The results indicate that the expression of miRNAs changes during differentiation of ADSCs. In addition, miRNAs regulate the differentiation of ADSCs into adipocytes, osteoblasts, chondrocytes, neurons, and hepatocytes by regulating the signaling pathways involved in cell differentiation. Conclusion: Through controlling the differentiation of ADSCs by miRNAs, the suitable seed cell for tissue engineering can be established. The review will provide a theoretical basis for molecular targeted therapy and stem cell therapy in clinic.
Objective: To review the research progress of miRNA regulation in the differentiation of adipose-derived stem cells (ADSCs). Methods: The recent literature associated with miRNAs and differentiation of ADSCs was reviewed. The regulatory mechanism was analyzed in detail and summarized. Results: The results indicate that the expression of miRNAs changes during differentiation of ADSCs. In addition, miRNAs regulate the differentiation of ADSCs into adipocytes, osteoblasts, chondrocytes, neurons, and hepatocytes by regulating the signaling pathways involved in cell differentiation. Conclusion: Through controlling the differentiation of ADSCs by miRNAs, the suitable seed cell for tissue engineering can be established. The review will provide a theoretical basis for molecular targeted therapy and stem cell therapy in clinic.