Kostas Konstantopoulos1,2, Eleni Zamba-Papanicolaou3,4, Kyproula Christodoulou5,4. 1. European University Cyprus, 6 Diogenous Street, Engomi, 2404, P.O. Box 22006, 1516, Nicosia, Cyprus. c.constantopoulos@euc.ac.cy. 2. Neurology Clinic D, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. c.constantopoulos@euc.ac.cy. 3. Neurology Clinic D, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. 4. Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. 5. Neurogenetics Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Abstract
BACKGROUND: Dysarthrophonia is often reported by hereditary spastic paraplegia (HSP) patients with SPG11 mutations but it has been poorly investigated. OBJECTIVE: The goal of this study was to investigate dysarthrophonia in SPG11 patients using quantitative measures. The voice/speech of two patients and a non-affected mutation carrier was recorded and analyzed using electroglottography (EGG) and speech acoustics. RESULTS: Dysarthrophonia showed a higher standard deviation of the average fundamental frequency, a three to eight times higher jitter, a 80-110 Hz higher mean fundamental frequency, and a two times higher fundamental frequency range. Diadochokinesis showed a pattern of a two to three times increase in the mean duration of the release burst of the phonemes /p/, /t/, /k/ as well as a 1.5 time increase in the mean vowel duration of the syllables /pa/, /ta/, /ka/. CONCLUSION: Non-invasive physiological methods (EGG and speech acoustics) offer essential tools for the assessment of dysarthrophonia in SPG11 patients.
BACKGROUND: Dysarthrophonia is often reported by hereditary spastic paraplegia (HSP) patients with SPG11 mutations but it has been poorly investigated. OBJECTIVE: The goal of this study was to investigate dysarthrophonia in SPG11patients using quantitative measures. The voice/speech of two patients and a non-affected mutation carrier was recorded and analyzed using electroglottography (EGG) and speech acoustics. RESULTS: Dysarthrophonia showed a higher standard deviation of the average fundamental frequency, a three to eight times higher jitter, a 80-110 Hz higher mean fundamental frequency, and a two times higher fundamental frequency range. Diadochokinesis showed a pattern of a two to three times increase in the mean duration of the release burst of the phonemes /p/, /t/, /k/ as well as a 1.5 time increase in the mean vowel duration of the syllables /pa/, /ta/, /ka/. CONCLUSION: Non-invasive physiological methods (EGG and speech acoustics) offer essential tools for the assessment of dysarthrophonia in SPG11patients.
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