G B Joseph1, M C Nevitt2, C E McCulloch3, J Neumann4, J A Lynch5, U Heilmeier6, N E Lane7, T M Link8. 1. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: gabby.joseph@ucsf.edu. 2. Department of Epidemiology and Biostatistics, University of California, San Francisco, USA. Electronic address: mnevitt@psg.ucsf.edu. 3. Department of Epidemiology and Biostatistics, University of California, San Francisco, USA. Electronic address: Charles.McCulloch@ucsf.edu. 4. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: Jan.Neumann@ucsf.edu. 5. Department of Epidemiology and Biostatistics, University of California, San Francisco, USA. Electronic address: jlynch@psg.ucsf.edu. 6. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: Ursula.Heilmeier@ucsf.edu. 7. Department of Rheumatology, University of California, Davis, USA. Electronic address: nelane@ucdavis.edu. 8. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: Thomas.Link@ucsf.edu.
Abstract
OBJECTIVE: The purpose of this study was to assess the associations between serum/urine biomarkers for osteoarthritis and magnetic resonance (MR) imaging measures of cartilage composition and joint structure (cartilage, meniscus, and bone marrow), using MR imaging data from the Osteoarthritis Initiative (OAI). DESIGN: 141 subjects with Kellgren Lawrence (KL) grades 0-3 in the right knee and with available serum/urine biomarker assays were selected from the OAI. Cartilage magnetic resonance imaging (MRI) T2 measurements were performed in the medial femur, lateral femur, medial tibia, lateral tibia, and patella compartments. Compartment-specific knee morphologic grading [whole-organ magnetic resonance imaging score (WORMS)] in the cartilage, meniscus, and bone marrow was also performed. We focused on associations of serum hyaluronan (sHA), serum cartilage oligomeric matrix protein (sCOMP), serum matrix metalloproteinase-3 (sMMP3), and Urine Carboxy-Terminal Telepeptides of Type II Collagen (uCtX-II)) with MRI parameters (T2, WORMS), assessed using partial correlations adjusted for age, gender, body mass index (BMI), KL grade in both knees, and diabetes status. RESULTS: Higher levels of sHA, sMMP3 and sCOMP were correlated (P < 0.05) with T2 of the lateral femur (r = 0.18 to 0.32) and lateral tibia (r = 0.17 to 0.23), and with average T2 of all knee regions (r = 0.23). uCTXII was correlated with patellar T2 (r = 0.19, P = 0.04). Among the morphologic measures, sHA and sMMP3 was positively correlated (r = 0.17 to 0.21, P < 0.05) with meniscal damage. CONCLUSIONS: This study suggests weak, but statistically significant, correlations between serum biomarkers of OA (sHA, sCOMP, and sMMP3) and MRI T2 measures of cartilage extra-cellular matrix degeneration.
OBJECTIVE: The purpose of this study was to assess the associations between serum/urine biomarkers for osteoarthritis and magnetic resonance (MR) imaging measures of cartilage composition and joint structure (cartilage, meniscus, and bone marrow), using MR imaging data from the Osteoarthritis Initiative (OAI). DESIGN: 141 subjects with Kellgren Lawrence (KL) grades 0-3 in the right knee and with available serum/urine biomarker assays were selected from the OAI. Cartilage magnetic resonance imaging (MRI) T2 measurements were performed in the medial femur, lateral femur, medial tibia, lateral tibia, and patella compartments. Compartment-specific knee morphologic grading [whole-organ magnetic resonance imaging score (WORMS)] in the cartilage, meniscus, and bone marrow was also performed. We focused on associations of serum hyaluronan (sHA), serum cartilage oligomeric matrix protein (sCOMP), serum matrix metalloproteinase-3 (sMMP3), and Urine Carboxy-Terminal Telepeptides of Type II Collagen (uCtX-II)) with MRI parameters (T2, WORMS), assessed using partial correlations adjusted for age, gender, body mass index (BMI), KL grade in both knees, and diabetes status. RESULTS: Higher levels of sHA, sMMP3 and sCOMP were correlated (P < 0.05) with T2 of the lateral femur (r = 0.18 to 0.32) and lateral tibia (r = 0.17 to 0.23), and with average T2 of all knee regions (r = 0.23). uCTXII was correlated with patellar T2 (r = 0.19, P = 0.04). Among the morphologic measures, sHA and sMMP3 was positively correlated (r = 0.17 to 0.21, P < 0.05) with meniscal damage. CONCLUSIONS: This study suggests weak, but statistically significant, correlations between serum biomarkers of OA (sHA, sCOMP, and sMMP3) and MRI T2 measures of cartilage extra-cellular matrix degeneration.
Authors: G B Joseph; T Baum; H Alizai; J Carballido-Gamio; L Nardo; W Virayavanich; J A Lynch; M C Nevitt; C E McCulloch; S Majumdar; T M Link Journal: Osteoarthritis Cartilage Date: 2012-04-11 Impact factor: 6.576
Authors: Patrick Garnero; Bernard Mazières; Alice Guéguen; Michel Abbal; Laurent Berdah; Michel Lequesne; Minh Nguyen; Jean-Pierre Salles; Eric Vignon; Maxime Dougados Journal: J Rheumatol Date: 2005-04 Impact factor: 4.666
Authors: Robert Stahl; Sapna K Jain; Jürgen Lutz; Bradley T Wyman; Marie-Pierre Hellio Le Graverand-Gastineau; Eric Vignon; Sharmila Majumdar; Thomas M Link Journal: Skeletal Radiol Date: 2011-04-09 Impact factor: 2.199
Authors: M Kretzschmar; W Lin; L Nardo; G B Joseph; D D Dunlop; U Heilmeier; M C Nevitt; H Alizai; C E McCulloch; J A Lynch; T M Link Journal: Arthritis Care Res (Hoboken) Date: 2015-09 Impact factor: 4.794
Authors: C G Peterfy; A Guermazi; S Zaim; P F J Tirman; Y Miaux; D White; M Kothari; Y Lu; K Fye; S Zhao; H K Genant Journal: Osteoarthritis Cartilage Date: 2004-03 Impact factor: 6.576
Authors: Virginia B Kraus; David E Hargrove; David J Hunter; Jordan B Renner; Joanne M Jordan Journal: Ann Rheum Dis Date: 2016-06-24 Impact factor: 19.103
Authors: Gabby B Joseph; Thomas Baum; Julio Carballido-Gamio; Lorenzo Nardo; Warapat Virayavanich; Hamza Alizai; John A Lynch; Charles E McCulloch; Sharmila Majumdar; Thomas M Link Journal: Arthritis Res Ther Date: 2011-09-20 Impact factor: 5.156
Authors: Yao Liu; Gabby B Joseph; Sarah C Foreman; Xiaoming Li; Nancy E Lane; Michael C Nevitt; Charles E McCulloch; Thomas M Link Journal: AJR Am J Roentgenol Date: 2020-07-29 Impact factor: 3.959
Authors: Yao Liu; Sarah C Foreman; Gabby B Joseph; Jan Neumann; Phyllis C Tien; Xiaoming Li; Nancy E Lane; Michael C Nevitt; Charles E McCulloch; Thomas M Link Journal: BMC Musculoskelet Disord Date: 2019-05-04 Impact factor: 2.362