Toshiaki Miyamoto1, Toshio Iwakura2, Naoki Matsuoka2, Masako Iwamoto3, Mariko Takenaka3, Yasunori Akamatsu4, Toshio Moritani4. 1. School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Japan. Electronic address: t-miyamoto@huhs.ac.jp. 2. Department of Diabetes and Endocrinology, Kobe City Medical Center General Hospital, Kobe, Japan. 3. Nutrition Management Department, Kobe City Medical Center General Hospital, Kobe, Japan. 4. Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan.
Abstract
AIMS: This study aimed to examine the effect of prolonged neuromuscular electrical stimulation (NMES) on the metabolic profile and cognition-related blood parameters in patients with type 2 diabetes mellitus (T2DM). METHODS:Fourteen patients with T2DM (63.2 ± 3.0 years, 76.1 ± 3.5 kg) participated in a randomized controlled cross-over study, in which 8-week-long NMES interventions were performed on both legs. The NMES training protocol consisted of 40-min sessions, 5 days per week, for 8 weeks. The relative changes in glucose and lipid profiles, and cognition-related blood parameters were evaluated. RESULTS:NMES training induced significant changes in the fasting glucose concentration (p < 0.05) and percent body fat (p < 0.05), although there were no significant changes in HbA1c and blood lipid levels (p ≥ 0.05). The change in plasma brain-derived neurotrophic factor (BDNF) levels was significantly higher in the NMES period than in the control period (p < 0.05). CONCLUSIONS: This study showed that an 8-week NMES training program could induce greater changes in the blood glucose concentration, percent body fat, and plasma BDNF levels than the control intervention in patients with T2DM. NMES training might prove to be an alternative exercise method for patients who might have difficulties in performing adequate voluntary exercise.
RCT Entities:
AIMS: This study aimed to examine the effect of prolonged neuromuscular electrical stimulation (NMES) on the metabolic profile and cognition-related blood parameters in patients with type 2 diabetes mellitus (T2DM). METHODS: Fourteen patients with T2DM (63.2 ± 3.0 years, 76.1 ± 3.5 kg) participated in a randomized controlled cross-over study, in which 8-week-long NMES interventions were performed on both legs. The NMES training protocol consisted of 40-min sessions, 5 days per week, for 8 weeks. The relative changes in glucose and lipid profiles, and cognition-related blood parameters were evaluated. RESULTS: NMES training induced significant changes in the fasting glucose concentration (p < 0.05) and percent body fat (p < 0.05), although there were no significant changes in HbA1c and blood lipid levels (p ≥ 0.05). The change in plasma brain-derived neurotrophic factor (BDNF) levels was significantly higher in the NMES period than in the control period (p < 0.05). CONCLUSIONS: This study showed that an 8-week NMES training program could induce greater changes in the blood glucose concentration, percent body fat, and plasma BDNF levels than the control intervention in patients with T2DM. NMES training might prove to be an alternative exercise method for patients who might have difficulties in performing adequate voluntary exercise.
Authors: Maja Rubinowicz-Zasada; Ewa Kucio; Anna Polak; Petr Stastny; Krzysztof Wierzbicki; Piotr Król; Cezary Kucio Journal: Int J Environ Res Public Health Date: 2021-03-26 Impact factor: 3.390