Lingjuan He1,2, Bin Zhou3,4,5,6. 1. The State Key Laboratory of Cell Biology, CAS Center for Excellence on Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. 2. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. 3. The State Key Laboratory of Cell Biology, CAS Center for Excellence on Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. zhoubin@sibs.ac.cn. 4. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. zhoubin@sibs.ac.cn. 5. School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. zhoubin@sibs.ac.cn. 6. Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, 510632, China. zhoubin@sibs.ac.cn.
Abstract
PURPOSE OF REVIEW: In this review, we aim to summarize and discuss the cellular origins of the coronary endothelial cells during development and neovascularization in the adult stage after cardiac injury. RECENT FINDINGS: Recent work identified three different developmental origins for coronary endothelial cells: proepicardium, endocardium, and sinus venosus. However, the level of contribution by each source remains debated. During heart injury and regeneration, although multiple cell types such as endothelial progenitor cells, epicardial cells, and endocardial cells were reported to contribute neovascularization, convincing evidence is still lacking.. Recently, fibroblasts were reported to contribute to endothelial cells after cardiac injury through mesenchymal-to-endothelial transition. A subsequent study demonstrated that pre-existing endothelial cells mainly mediate cardiac neovascularization after injury. The developmental origins of coronary vessels are diverse and further studies are needed to address the exact contribution from each source and the molecular mechanism governing distinct vessel formation programs. In the adult stage, neovascularization is mainly mediated by the pre-existing endothelial cells, with negligible contribution from other sources.
PURPOSE OF REVIEW: In this review, we aim to summarize and discuss the cellular origins of the coronary endothelial cells during development and neovascularization in the adult stage after cardiac injury. RECENT FINDINGS: Recent work identified three different developmental origins for coronary endothelial cells: proepicardium, endocardium, and sinus venosus. However, the level of contribution by each source remains debated. During heart injury and regeneration, although multiple cell types such as endothelial progenitor cells, epicardial cells, and endocardial cells were reported to contribute neovascularization, convincing evidence is still lacking.. Recently, fibroblasts were reported to contribute to endothelial cells after cardiac injury through mesenchymal-to-endothelial transition. A subsequent study demonstrated that pre-existing endothelial cells mainly mediate cardiac neovascularization after injury. The developmental origins of coronary vessels are diverse and further studies are needed to address the exact contribution from each source and the molecular mechanism governing distinct vessel formation programs. In the adult stage, neovascularization is mainly mediated by the pre-existing endothelial cells, with negligible contribution from other sources.
Authors: Tamar C Katz; Manvendra K Singh; Karl Degenhardt; José Rivera-Feliciano; Randy L Johnson; Jonathan A Epstein; Clifford J Tabin Journal: Dev Cell Date: 2012-03-13 Impact factor: 12.270
Authors: Jamie L Russell; Sean C Goetsch; Nicholas R Gaiano; Joseph A Hill; Eric N Olson; Jay W Schneider Journal: Circ Res Date: 2010-11-24 Impact factor: 17.367
Authors: Bin Zhou; Leah B Honor; Huamei He; Qing Ma; Jin-Hee Oh; Catherine Butterfield; Ruei-Zeng Lin; Juan M Melero-Martin; Elena Dolmatova; Heather S Duffy; Alexander von Gise; Pingzhu Zhou; Yong Wu Hu; Gang Wang; Bing Zhang; Lianchun Wang; Jennifer L Hall; Marsha A Moses; Francis X McGowan; William T Pu Journal: J Clin Invest Date: 2011-04-18 Impact factor: 14.808
Authors: Bingruo Wu; Zheng Zhang; Wendy Lui; Xiangjian Chen; Yidong Wang; Alyssa A Chamberlain; Ricardo A Moreno-Rodriguez; Roger R Markwald; Brian P O'Rourke; David J Sharp; Deyou Zheng; Jack Lenz; H Scott Baldwin; Ching-Pin Chang; Bin Zhou Journal: Cell Date: 2012-11-21 Impact factor: 41.582