Literature DB >> 29802141

A missed Fe-S cluster handoff causes a metabolic shakeup.

Olivier Berteau1.   

Abstract

The general framework of pathways by which iron-sulfur (Fe-S) clusters are assembled in cells is well-known, but the cellular consequences of disruptions to that framework are not fully understood. Crooks et al. report a novel cellular system that creates an acute Fe-S cluster deficiency, using mutants of ISCU, the main scaffold protein for Fe-S cluster assembly. Surprisingly, the resultant metabolic reprogramming leads to the accumulation of lipid droplets, a situation encountered in many poorly understood pathological conditions, highlighting unanticipated links between Fe-S assembly machinery and human disease.
© 2018 Berteau.

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Year:  2018        PMID： 29802141      PMCID： PMC5971438          DOI： 10.1074/jbc.H118.002883

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  NifS-directed assembly of a transient [2Fe-2S] cluster within the NifU protein.

Authors:  P Yuvaniyama; J N Agar; V L Cash; M K Johnson; D R Dean
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

2.  Mechanistic investigations of lipoic acid biosynthesis in Escherichia coli: both sulfur atoms in lipoic acid are contributed by the same lipoyl synthase polypeptide.

Authors:  Robert M Cicchillo; Squire J Booker
Journal:  J Am Chem Soc       Date:  2005-03-09       Impact factor: 15.419

Review 3.  Structure, function, and formation of biological iron-sulfur clusters.

Authors:  Deborah C Johnson; Dennis R Dean; Archer D Smith; Michael K Johnson
Journal:  Annu Rev Biochem       Date:  2005       Impact factor: 23.643

Review 4.  DNA Repair by the Radical SAM Enzyme Spore Photoproduct Lyase: From Biochemistry to Structural Investigations.

Authors:  Olivier Berteau; Alhosna Benjdia
Journal:  Photochem Photobiol       Date:  2017-01-27       Impact factor: 3.421

5.  Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells.

Authors:  Daniel R Crooks; Nunziata Maio; Andrew N Lane; Michal Jarnik; Richard M Higashi; Ronald G Haller; Ye Yang; Teresa W-M Fan; W Marston Linehan; Tracey A Rouault
Journal:  J Biol Chem       Date:  2018-03-09       Impact factor: 5.157

Review 6.  Maturation of cytosolic and nuclear iron-sulfur proteins.

Authors:  Daili J A Netz; Judita Mascarenhas; Oliver Stehling; Antonio J Pierik; Roland Lill
Journal:  Trends Cell Biol       Date:  2013-12-03       Impact factor: 20.808

7.  Tissue-specific splicing of ISCU results in a skeletal muscle phenotype in myopathy with lactic acidosis, while complete loss of ISCU results in early embryonic death in mice.

Authors:  Angelica Nordin; Elin Larsson; Lars-Eric Thornell; Monica Holmberg
Journal:  Hum Genet       Date:  2010-12-17       Impact factor: 4.132

Review 8.  Sulfatases and radical SAM enzymes: emerging themes in glycosaminoglycan metabolism and the human microbiota.

Authors:  Alhosna Benjdia; Olivier Berteau
Journal:  Biochem Soc Trans       Date:  2016-02       Impact factor: 5.407

Review 9.  Mammalian iron-sulphur proteins: novel insights into biogenesis and function.

Authors:  Tracey A Rouault
Journal:  Nat Rev Mol Cell Biol       Date:  2014-11-26       Impact factor: 94.444

Review 10.  Balancing the fat: lipid droplets and human disease.

Authors:  Natalie Krahmer; Robert V Farese; Tobias C Walther
Journal:  EMBO Mol Med       Date:  2013-06-06       Impact factor: 12.137
  10 in total
  3 in total

1.  The Potential Regulatory Roles of lncRNAs in DNA Damage Response in Human Lymphocytes Exposed to UVC Irradiation.

Authors:  Dan Xu; Yue Wang; Jia Wang; Fei Qi; Yeqing Sun
Journal:  Biomed Res Int       Date:  2020-03-13       Impact factor: 3.411

Review 2.  Radical SAM Enzymes and Ribosomally-Synthesized and Post-translationally Modified Peptides: A Growing Importance in the Microbiomes.

Authors:  Alhosna Benjdia; Olivier Berteau
Journal:  Front Chem       Date:  2021-07-19       Impact factor: 5.221

Review 3.  Links Between Iron and Lipids: Implications in Some Major Human Diseases.

Authors:  Stephanie Rockfield; Ravneet Chhabra; Michelle Robertson; Nabila Rehman; Richa Bisht; Meera Nanjundan
Journal:  Pharmaceuticals (Basel)       Date:  2018-10-22
  3 in total

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