Yueqi Zhang1, Chunfang Wang2, Ying Wang1, Qin Xiao1, Jun Liu1, Jianfang Ma1, Haiyan Zhou1, Jing Pan1, Yuyan Tan1, Shengdi Chen1, Gang Xu3, Gang Wang4. 1. Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai, Jiao Tong University School of Medicine, Shanghai, 200025, China. 2. Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. 3. School of Public Health, Shanghai Jiao Tong University, Shanghai, 200025, China. Electronic address: xugang567@sina.com. 4. Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai, Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address: wg11424@rjh.com.cn.
Abstract
BACKGROUND: Standardized mortality ratio (SMR) is the most frequently used index in Parkinson's disease (PD) survival survey. However, there is little SMR data in PD from China. OBJECTIVE: To examine the outcome, including overall and cause-specific mortality, of PD patients subsequent to 10 years of surveillance in Shanghai, China. This is an extension study of our previous investigation on mortality. METHODS: One hundred fifty-seven PD patients recruited from the movement disorder clinic of Rui Jin Hospital in 2006 were followed up until December 31, 2016 or death, representing a follow-up period of up to 10 years. Overall and cause-specific standardized mortality ratios (SMR) were calculated, and predictors for survival at disease onset were estimated. RESULTS: Thirty one patients had died by December 31, 2016, and the SMR at 10 years of follow-up was 0.87 (0.59-1.25). The primary direct cause of death was respiratory disease (SMR = 3.52, 95% CI 1.98-5.78). Employing Cox's proportional hazard modeling, postural instability gait disorder (PIGD) type and older age at onset predicted poor survival in this cohort. CONCLUSIONS: This finding confirms the similar survival of patients with PD to the control population in the post-levodopa era. PIGD type and older age at onset had a negative impact on survival.
BACKGROUND: Standardized mortality ratio (SMR) is the most frequently used index in Parkinson's disease (PD) survival survey. However, there is little SMR data in PD from China. OBJECTIVE: To examine the outcome, including overall and cause-specific mortality, of PDpatients subsequent to 10 years of surveillance in Shanghai, China. This is an extension study of our previous investigation on mortality. METHODS: One hundred fifty-seven PDpatients recruited from the movement disorder clinic of Rui Jin Hospital in 2006 were followed up until December 31, 2016 or death, representing a follow-up period of up to 10 years. Overall and cause-specific standardized mortality ratios (SMR) were calculated, and predictors for survival at disease onset were estimated. RESULTS: Thirty one patients had died by December 31, 2016, and the SMR at 10 years of follow-up was 0.87 (0.59-1.25). The primary direct cause of death was respiratory disease (SMR = 3.52, 95% CI 1.98-5.78). Employing Cox's proportional hazard modeling, postural instability gait disorder (PIGD) type and older age at onset predicted poor survival in this cohort. CONCLUSIONS: This finding confirms the similar survival of patients with PD to the control population in the post-levodopa era. PIGD type and older age at onset had a negative impact on survival.
Authors: Fulvio A Scorza; Marcia Guimarães-Marques; Mariana Nejm; Antônio Carlos G de Almeida; Carla A Scorza; Ana C Fiorini; Josef Finsterer Journal: Clinics (Sao Paulo) Date: 2022-02-10 Impact factor: 2.365