Hye-Ryun Yeh1, Hyo-Kyoung Park2, Hyun-Jin Kim1, Tae-Sung Ko1, Hye-Sung Won2, Mi-Young Lee2, Jae-Yoon Shim3, Mi-Sun Yum4. 1. Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea. 2. Department of Obstetrics & Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 3. Department of Obstetrics & Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: jyshim@amc.seoul.kr. 4. Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: yumyum99@daum.net.
Abstract
OBJECTIVE: Although corpus callosal abnormalities are among the most common brain malformations detected prenatally, few previous studies have described the neurodevelopmental outcomes of children with this condition. The aim of our study was to evaluate the neurodevelopmental outcomes and associated clinical features of children with corpus callosal abnormalities diagnosed by prenatal ultrasonography. METHODS: Between July 2011 and July 2016, forty-nine children with corpus callosal abnormalities were born in Asan Medical Center Children's Hospital. Neurodevelopmental assessments were conducted in 40 patients at a median age of 24.8 months using the Bayley Scales of Infant Development II or the Korean Infant and Child Development Test. Patients were categorized according to their postnatal magnetic resonance imaging (MRI) findings and accompanying anomalies. Baseline characteristics and developmental outcomes of each group were compared. RESULTS: Isolated agenesis or hypoplasia of the corpus callosum was found in 16 (32.7%) patients, other associated central nervous system (CNS) abnormalities were found in 28 (57.1%) patients, and non-CNS abnormalities were found in 11 (22.4%) patients. Among the 40 patients who underwent developmental assessment, 18 (45.0%) showed normal development and 10 (25.0%) showed moderate-to-severe global developmental delay. Seven of the twelve (58.3%) patients with isolated corpus callosal abnormalities showed normal development. The combination of corpus callosal abnormalities with non-CNS anomalies was significantly associated with developmental delay (odds ratio 2.5, 95% confidence interval 1.6-3.9, p = 0.001). Conversely, children with isolated corpus callosal abnormalities showed relatively favorable neurodevelopmental outcomes. CONCLUSION: Appropriate evaluation and comprehensive therapeutic approaches are strongly recommended for neonates who present with corpus callosal abnormalities combined with additional anomalies.
OBJECTIVE: Although corpus callosal abnormalities are among the most common brain malformations detected prenatally, few previous studies have described the neurodevelopmental outcomes of children with this condition. The aim of our study was to evaluate the neurodevelopmental outcomes and associated clinical features of children with corpus callosal abnormalities diagnosed by prenatal ultrasonography. METHODS: Between July 2011 and July 2016, forty-nine children with corpus callosal abnormalities were born in Asan Medical Center Children's Hospital. Neurodevelopmental assessments were conducted in 40 patients at a median age of 24.8 months using the Bayley Scales of Infant Development II or the Korean Infant and Child Development Test. Patients were categorized according to their postnatal magnetic resonance imaging (MRI) findings and accompanying anomalies. Baseline characteristics and developmental outcomes of each group were compared. RESULTS: Isolated agenesis or hypoplasia of the corpus callosum was found in 16 (32.7%) patients, other associated central nervous system (CNS) abnormalities were found in 28 (57.1%) patients, and non-CNS abnormalities were found in 11 (22.4%) patients. Among the 40 patients who underwent developmental assessment, 18 (45.0%) showed normal development and 10 (25.0%) showed moderate-to-severe global developmental delay. Seven of the twelve (58.3%) patients with isolated corpus callosal abnormalities showed normal development. The combination of corpus callosal abnormalities with non-CNS anomalies was significantly associated with developmental delay (odds ratio 2.5, 95% confidence interval 1.6-3.9, p = 0.001). Conversely, children with isolated corpus callosal abnormalities showed relatively favorable neurodevelopmental outcomes. CONCLUSION: Appropriate evaluation and comprehensive therapeutic approaches are strongly recommended for neonates who present with corpus callosal abnormalities combined with additional anomalies.
Authors: Javier De Las Heras; Ibai Diez; Antonio Jimenez-Marin; Alberto Cabrera; Daniela Ramos-Usuga; Marta Venecia Diaz-Fernandez; Leire Torices; Caroline E Nunes-Xavier; Rafael Pulido; Juan Carlos Arango-Lasprilla; Jesus M Cortes Journal: J Clin Med Date: 2020-04-02 Impact factor: 4.241
Authors: M C Diogo; S Glatter; D Prayer; G M Gruber; D Bettelheim; M Weber; G Dovjak; R Seidl; G Kasprian Journal: Ultrasound Obstet Gynecol Date: 2021-07 Impact factor: 8.678