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Literature DB >> 29801524

A Ca²⁺ Sensor for Exocytosis.

Abstract

In 1992, Brose et al. showed that the synaptic vesicle (SV) protein p65/synaptotagmin (syt) 1 binds - in a mutually dependent manner - Ca2+ and anionic phospholipids, prompting the idea that it functions as a Ca2+ sensor for exocytosis. These findings now define two key aspects of excitation-secretion coupling.

Entities: Chemical

Keywords: SNARE; exocytosis; membrane fusion; neurotransmitter

Mesh：

Substances：
Synaptotagmin I
Calcium

Year: 2018 PMID： 29801524 PMCID： PMC6051711 DOI： 10.1016/j.tins.2018.03.012

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

15 in total

1. The synaptotagmin C2A domain is part of the calcium sensor controlling fast synaptic transmission.

Authors: Charles F Stevens; Jane M Sullivan
Journal: Neuron Date: 2003-07-17 Impact factor: 17.173

2. Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine.

Authors: I Fernandez; D Araç; J Ubach; S H Gerber; O Shin; Y Gao; R G Anderson; T C Südhof; J Rizo
Journal: Neuron Date: 2001-12-20 Impact factor: 17.173

3. Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

Authors: N Brose; A G Petrenko; T C Südhof; R Jahn
Journal: Science Date: 1992-05-15 Impact factor: 47.728

4. Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers.

Authors: E R Chapman; A F Davis
Journal: J Biol Chem Date: 1998-05-29 Impact factor: 5.157

5. Transmitter release induced by injection of calcium ions into nerve terminals.

Authors: R Miledi
Journal: Proc R Soc Lond B Biol Sci Date: 1973-07-03

6. Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.

Authors: R B Sutton; B A Davletov; A M Berghuis; T C Südhof; S R Sprang
Journal: Cell Date: 1995-03-24 Impact factor: 41.582

Review 7. How does synaptotagmin trigger neurotransmitter release?

Authors: Edwin R Chapman
Journal: Annu Rev Biochem Date: 2008 Impact factor: 23.643

8. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C.

Authors: M S Perin; V A Fried; G A Mignery; R Jahn; T C Südhof
Journal: Nature Date: 1990-05-17 Impact factor: 49.962

9. Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.

Authors: Jihye Lee; Zhuo Guan; Yulia Akbergenova; J Troy Littleton
Journal: J Neurosci Date: 2013-01-02 Impact factor: 6.167

10. Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release.

Authors: Ok-Ho Shin; Jun Xu; Josep Rizo; Thomas C Südhof
Journal: Proc Natl Acad Sci U S A Date: 2009-09-04 Impact factor: 11.205

7 in total

1. Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B.

Authors: Alessandra Flores; Jorge Ramirez-Franco; Richard Desplantes; Kévin Debreux; Géraldine Ferracci; Florian Wernert; Marie-Pierre Blanchard; Yves Maulet; Fahamoe Youssouf; Marion Sangiardi; Cécile Iborra; Michel Robert Popoff; Michael Seagar; Jacques Fantini; Christian Lévêque; Oussama El Far
Journal: Proc Natl Acad Sci U S A Date: 2019-08-20 Impact factor: 11.205

7. A first-passage approach to diffusion-influenced reversible binding and its insights into nanoscale signaling at the presynapse.

Authors: Maria Reva; David A DiGregorio; Denis S Grebenkov
Journal: Sci Rep Date: 2021-03-08 Impact factor: 4.379