Bianca Maceo Heilman1,2, Fabrice Manns1,2, Marco Ruggeri1, Arthur Ho1,3,4, Alex Gonzalez1, Cor Rowaan1, Andres Bernal5, Esdras Arrieta1, Jean-Marie Parel1,2,6. 1. Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Miami, Florida, United States. 2. Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States. 3. Brien Holden Vision Institute, Sydney, New South Wales, Australia. 4. School of Optometry and Vision Science, University of New South Wales, Australia. 5. Bioniko Consulting LLC, Sunny Isles Beach, Florida, United States. 6. Vision Cooperative Research Centre, Sydney, New South Wales, Australia.
Abstract
Purpose: To characterize the peripheral defocus of the monkey crystalline lens and its changes with accommodation. Methods: Experiments were performed on 15 lenses from 11 cynomolgus monkey eyes (age: 3.8-12.4 years, postmortem time: 33.5 ± 15.3 hours). The tissue was mounted in a motorized lens stretcher to allow for measurements of the lens in the accommodated (unstretched) and unaccommodated (stretched) states. A custom-built combined laser ray tracing and optical coherence tomography system was used to measure the paraxial on-axis and off-axis lens power for delivery angles ranging from -20° to +20° (in air). For each delivery angle, peripheral defocus was quantified as the difference between paraxial off-axis and on-axis power. The peripheral defocus of the lens was compared in the unstretched and stretched states. Results: On average, the paraxial on-axis lens power was 52.0 ± 3.4 D in the unstretched state and 32.5 ± 5.1 D in the stretched state. In both states, the lens power increased with increasing delivery angle. From 0° to +20°, the relative peripheral lens power increased by 10.7 ± 1.4 D in the unstretched state and 7.5 ± 1.6 D in the stretched state. The change in field curvature with accommodation was statistically significant (P < 0.001), indicating that the unstretched (accommodated) lens has greater curvature or relative peripheral power. Conclusions: The cynomolgus monkey lens has significant accommodation-dependent curvature of field, which suggests that the lens asserts a significant contribution to the peripheral optical performance of the eye that also varies with the state of accommodation.
Purpose: To characterize the peripheral defocus of the monkey crystalline lens and its changes with accommodation. Methods: Experiments were performed on 15 lenses from 11 cynomolgus monkey eyes (age: 3.8-12.4 years, postmortem time: 33.5 ± 15.3 hours). The tissue was mounted in a motorized lens stretcher to allow for measurements of the lens in the accommodated (unstretched) and unaccommodated (stretched) states. A custom-built combined laser ray tracing and optical coherence tomography system was used to measure the paraxial on-axis and off-axis lens power for delivery angles ranging from -20° to +20° (in air). For each delivery angle, peripheral defocus was quantified as the difference between paraxial off-axis and on-axis power. The peripheral defocus of the lens was compared in the unstretched and stretched states. Results: On average, the paraxial on-axis lens power was 52.0 ± 3.4 D in the unstretched state and 32.5 ± 5.1 D in the stretched state. In both states, the lens power increased with increasing delivery angle. From 0° to +20°, the relative peripheral lens power increased by 10.7 ± 1.4 D in the unstretched state and 7.5 ± 1.6 D in the stretched state. The change in field curvature with accommodation was statistically significant (P < 0.001), indicating that the unstretched (accommodated) lens has greater curvature or relative peripheral power. Conclusions: The cynomolgus monkey lens has significant accommodation-dependent curvature of field, which suggests that the lens asserts a significant contribution to the peripheral optical performance of the eye that also varies with the state of accommodation.
Authors: Anne Seidemann; Frank Schaeffel; Antonio Guirao; Noberto Lopez-Gil; Pablo Artal Journal: J Opt Soc Am A Opt Image Sci Vis Date: 2002-12 Impact factor: 2.129
Authors: Bianca M Maceo; Fabrice Manns; David Borja; Derek Nankivil; Stephen Uhlhorn; Esdras Arrieta; Arthur Ho; Robert C Augusteyn; Jean-Marie Parel Journal: J Vis Date: 2011-11-30 Impact factor: 2.240
Authors: Andrew Whatham; Frederik Zimmermann; Aldo Martinez; Stephanie Delgado; Percy Lazon de la Jara; Padmaja Sankaridurg; Arthur Ho Journal: J Vis Date: 2009-03-20 Impact factor: 2.240
Authors: David Borja; Fabrice Manns; Arthur Ho; Noel M Ziebarth; Ana Carolina Acosta; Esdras Arrieta-Quintera; Robert C Augusteyn; Jean-Marie Parel Journal: Invest Ophthalmol Vis Sci Date: 2010-01-27 Impact factor: 4.799