David Bursill1, William J Taylor2, Robert Terkeltaub3, Masanari Kuwabara4, Tony R Merriman5, Rebecca Grainger2, Carlos Pineda6, Worawit Louthrenoo7, N Lawrence Edwards8, Mariano Andrés9, Ana Beatriz Vargas-Santos10, Edward Roddy11, Tristan Pascart12, Ching-Tsai Lin13, Fernando Perez-Ruiz14, Sara K Tedeschi15, Seoyoung C Kim15, Leslie R Harrold16, Geraldine McCarthy17, Nitin Kumar18, Peter T Chapman19, Anne-Kathrin Tausche20, Janitzia Vazquez-Mellado21, Marwin Gutierrez22, Geraldo da Rocha Castelar-Pinheiro10, Pascal Richette23, Eliseo Pascual9, Mark C Fisher24, Ruben Burgos-Vargas21, Philip C Robinson25, Jasvinder A Singh26, Tim L Jansen27, Kenneth G Saag28, Ole Slot29, Tillmann Uhlig30, Daniel H Solomon15, Robert T Keenan31, Carlo Alberto Scire32, Edyta Biernat-Kaluza33, Mats Dehlin34, George Nuki35, Naomi Schlesinger36, Matthijs Janssen27, Lisa K Stamp37, Francisca Sivera38, Anthony M Reginato39, Lennart Jacobsson34, Frédéric Lioté23, Hang-Korng Ea23, Ann Rosenthal40, Thomas Bardin23, Hyon K Choi24, Michael S Hershfield41, Christine Czegley42, Sung Jae Choi43, Nicola Dalbeth44. 1. University of Auckland, Auckland, New Zealand, and Adelaide Medical School, University of Adelaide, South Australia, Australia. 2. University of Otago, Wellington, and Hutt Valley District Health Board, Lower Hutt, New Zealand. 3. Veterans Affairs Medical Center and University of California, San Diego. 4. Toranomon Hospital, Tokyo, Japan, and University of Colorado Denver, Aurora. 5. University of Otago, Dunedin, New Zealand. 6. Instituto Nacional Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico. 7. Chiang Mai University, Chiang Mai, Thailand. 8. University of Florida College of Medicine, Gainesville. 9. Hospital Universitario de Alicante and Universidad Miguel Hernández, Alicante, Spain. 10. State University of Rio de Janeiro, Rio de Janeiro, Brazil. 11. Keele University, Keele, UK. 12. Lille Catholic University and Saint-Philibert Hospital, Lomme, France. 13. Taichung Veterans General Hospital, Taichung, Taiwan. 14. University of the Basque Country, Biscay, and Cruces University Hospital and Biocruces Health Research Institute, Baracaldo, Spain. 15. Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts. 16. Corrona, LLC, Waltham, and University of Massachusetts Medical School, Worcester. 17. Mater Misericordiae University Hospital and University College, Dublin, Ireland. 18. Henry Ford Hospital, Detroit, Michigan. 19. Christchurch Hospital, Christchurch, New Zealand. 20. University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany. 21. Hospital General de México and Universidad Nacional Autónoma de México, Mexico City, Mexico. 22. Instituto Nacional Rehabilitación, Mexico City, Mexico. 23. Hôpital Lariboisière, Assistance Publique-Hopitaux de Paris, and INSERM UMR-1132 and Université Paris Diderot, Paris, France. 24. Harvard Medical School and Massachusetts General Hospital Boston. 25. University of Queensland School of Medicine and Royal Brisbane and Women's Hospital, Herston, Queensland, Australia. 26. Veterans Affairs Medical Center, Birmingham, and University of Alabama at Birmingham. 27. Viecuri Medical Centre, Venlo, The Netherlands. 28. University of Alabama at Birmingham. 29. Rigshospitalet Glostrup, Glostrup, Denmark. 30. Diakonhjemmet Hospital, Oslo, Norway. 31. Duke University School of Medicine, Durham, North Carolina. 32. University of Ferrara, Ferrara, and Italian Society for Rheumatology, Milan, Italy. 33. ORLIK, Warsaw, Poland. 34. Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 35. University of Edinburgh, Edinburgh, UK. 36. Rutgers-Robert Wood Johnson Medical School, Piscataway, New Jersey. 37. University of Otago, Christchurch, New Zealand. 38. Hospital General Universitario de Elda, Alicante, Spain. 39. Warren Alpert School of Medicine at Brown University, Providence, Rhode Island. 40. Medical College of Wisconsin and the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee. 41. Duke University Medical Center, Durham, North Carolina. 42. Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany. 43. University of California, San Diego, and Korea University Ansan Hospital, Ansan, South Korea. 44. University of Auckland, Auckland, New Zealand.
Abstract
OBJECTIVE: The language currently used to describe gout lacks standardization. The aim of this project was to develop a consensus statement on the labels and definitions used to describe the basic disease elements of gout. METHODS: Experts in gout (n = 130) were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach consensus on the labeling and definitions for the basic disease elements of gout. Disease elements and labels in current use were derived from a content analysis of the contemporary medical literature, and the results of this analysis were used for item selection in the Delphi exercise and face-to-face consensus meeting. RESULTS: There were 51 respondents to the Delphi exercise and 30 attendees at the face-to-face meeting. Consensus agreement (≥80%) was achieved for the labels of 8 disease elements through the Delphi exercise; the remaining 3 labels reached consensus agreement through the face-to-face consensus meeting. The agreed labels were monosodium urate crystals, urate, hyperuric(a)emia, tophus, subcutaneous tophus, gout flare, intercritical gout, chronic gouty arthritis, imaging evidence of monosodium urate crystal deposition, gouty bone erosion, and podagra. Participants at the face-to-face meeting achieved consensus agreement for the definitions of all 11 elements and a recommendation that the label "chronic gout" should not be used. CONCLUSION: Consensus agreement was achieved for the labels and definitions of 11 elements representing the fundamental components of gout etiology, pathophysiology, and clinical presentation. The Gout, Hyperuricemia, and Crystal-Associated Disease Network recommends the use of these labels when describing the basic disease elements of gout.
OBJECTIVE: The language currently used to describe gout lacks standardization. The aim of this project was to develop a consensus statement on the labels and definitions used to describe the basic disease elements of gout. METHODS: Experts in gout (n = 130) were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach consensus on the labeling and definitions for the basic disease elements of gout. Disease elements and labels in current use were derived from a content analysis of the contemporary medical literature, and the results of this analysis were used for item selection in the Delphi exercise and face-to-face consensus meeting. RESULTS: There were 51 respondents to the Delphi exercise and 30 attendees at the face-to-face meeting. Consensus agreement (≥80%) was achieved for the labels of 8 disease elements through the Delphi exercise; the remaining 3 labels reached consensus agreement through the face-to-face consensus meeting. The agreed labels were monosodium urate crystals, urate, hyperuric(a)emia, tophus, subcutaneous tophus, gout flare, intercritical gout, chronic gouty arthritis, imaging evidence of monosodium urate crystal deposition, gouty bone erosion, and podagra. Participants at the face-to-face meeting achieved consensus agreement for the definitions of all 11 elements and a recommendation that the label "chronic gout" should not be used. CONCLUSION: Consensus agreement was achieved for the labels and definitions of 11 elements representing the fundamental components of gout etiology, pathophysiology, and clinical presentation. The Gout, Hyperuricemia, and Crystal-Associated Disease Network recommends the use of these labels when describing the basic disease elements of gout.
Authors: Paul G Shekelle; Sydne J Newberry; John D FitzGerald; Aneesa Motala; Claire E O'Hanlon; Abdul Tariq; Adeyemi Okunogbe; Dan Han; Roberta Shanman Journal: Ann Intern Med Date: 2016-11-01 Impact factor: 25.391
Authors: N Lawrence Edwards; Robert Malouf; Fernando Perez-Ruiz; Pascal Richette; Siobhan Southam; Matthew DiChiara Journal: Arthritis Care Res (Hoboken) Date: 2016-06 Impact factor: 4.794
Authors: David Bursill; William J Taylor; Robert Terkeltaub; Abhishek Abhishek; Alexander K So; Ana Beatriz Vargas-Santos; Angelo Lino Gaffo; Ann Rosenthal; Anne-Kathrin Tausche; Anthony Reginato; Bernhard Manger; Carlo Sciré; Carlos Pineda; Caroline van Durme; Ching-Tsai Lin; Congcong Yin; Daniel Arthur Albert; Edyta Biernat-Kaluza; Edward Roddy; Eliseo Pascual; Fabio Becce; Fernando Perez-Ruiz; Francisca Sivera; Frédéric Lioté; Georg Schett; George Nuki; Georgios Filippou; Geraldine McCarthy; Geraldo da Rocha Castelar Pinheiro; Hang-Korng Ea; Helena De Almeida Tupinambá; Hisashi Yamanaka; Hyon K Choi; James Mackay; James R ODell; Janitzia Vázquez Mellado; Jasvinder A Singh; John D Fitzgerald; Lennart T H Jacobsson; Leo Joosten; Leslie R Harrold; Lisa Stamp; Mariano Andrés; Marwin Gutierrez; Masanari Kuwabara; Mats Dehlin; Matthijs Janssen; Michael Doherty; Michael S Hershfield; Michael Pillinger; N Lawrence Edwards; Naomi Schlesinger; Nitin Kumar; Ole Slot; Sebastien Ottaviani; Pascal Richette; Paul A MacMullan; Peter T Chapman; Peter E Lipsky; Philip Robinson; Puja P Khanna; Rada N Gancheva; Rebecca Grainger; Richard J Johnson; Ritch Te Kampe; Robert T Keenan; Sara K Tedeschi; Seoyoung Kim; Sung Jae Choi; Theodore R Fields; Thomas Bardin; Till Uhlig; Tim Jansen; Tony Merriman; Tristan Pascart; Tuhina Neogi; Viola Klück; Worawit Louthrenoo; Nicola Dalbeth Journal: Ann Rheum Dis Date: 2019-09-09 Impact factor: 19.103
Authors: Lisandro D Colantonio; Richard J Reynolds; Tony R Merriman; Angelo Gaffo; Jasvinder A Singh; Timothy B Plante; Ninad S Chaudhary; Nicole D Armstrong; Elsayed Z Soliman; Jeffrey R Curtis; S Louis Bridges; Leslie Lang; George Howard; Monika M Safford; Kenneth G Saag; Paul Muntner; Marguerite Ryan Irvin Journal: J Rheumatol Date: 2021-06-15 Impact factor: 4.666