Literature DB >> 29799562

How T cells go rogue in the absence of Roquins.

Abdalla Akef1, Stefan A Muljo1.   

Abstract

Roquin-1 and Roquin-2 are RNA-binding proteins essential for modulating T cell activity. Indeed, Roquin dysfunction has been linked to autoimmunity in mice. Essig and colleagues (2017) determine their functions in Foxp3+ T regulatory cells and uncover novel mechanisms of Roquin-mediated regulation of its target mRNAs (1).

Entities:  

Keywords:  Gene expression; RNA-binding proteins; immunology

Year:  2018        PMID： 29799562      PMCID： PMC5963713          DOI： 10.21037/ncri.2018.03.08

Source DB:  PubMed          Journal:  Noncoding RNA Investig        ISSN： 2522-6673


  25 in total

1.  The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells.

Authors:  Nengming Xiao; Danelle Eto; Chris Elly; Guiying Peng; Shane Crotty; Yun-Cai Liu
Journal:  Nat Immunol       Date:  2014-05-25       Impact factor: 25.606

2.  RNA-protein interaction detection in living cells.

Authors:  Muthukumar Ramanathan; Karim Majzoub; Deepti S Rao; Poornima H Neela; Brian J Zarnegar; Smarajit Mondal; Julien G Roth; Hui Gai; Joanna R Kovalski; Zurab Siprashvili; Theo D Palmer; Jan E Carette; Paul A Khavari
Journal:  Nat Methods       Date:  2018-02-05       Impact factor: 28.547

3.  Roquin binding to target mRNAs involves a winged helix-turn-helix motif.

Authors:  Anja Schuetz; Yasuhiro Murakawa; Eva Rosenbaum; Markus Landthaler; Udo Heinemann
Journal:  Nat Commun       Date:  2014-12-11       Impact factor: 14.919

4.  A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.

Authors:  Carola G Vinuesa; Matthew C Cook; Constanza Angelucci; Vicki Athanasopoulos; Lixin Rui; Kim M Hill; Di Yu; Heather Domaschenz; Belinda Whittle; Teresa Lambe; Ian S Roberts; Richard R Copley; John I Bell; Richard J Cornall; Christopher C Goodnow
Journal:  Nature       Date:  2005-05-26       Impact factor: 49.962

5.  The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs.

Authors:  Vicki Athanasopoulos; Andrew Barker; Di Yu; Andy H-M Tan; Monika Srivastava; Nelida Contreras; Jianbin Wang; Kong-Peng Lam; Simon H J Brown; Christopher C Goodnow; Nicholas E Dixon; Peter J Leedman; Robert Saint; Carola G Vinuesa
Journal:  FEBS J       Date:  2010-05       Impact factor: 5.542

6.  Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression.

Authors:  Elke Glasmacher; Kai P Hoefig; Katharina U Vogel; Nicola Rath; Lirui Du; Christine Wolf; Elisabeth Kremmer; Xiaozhong Wang; Vigo Heissmeyer
Journal:  Nat Immunol       Date:  2010-07-18       Impact factor: 25.606

7.  Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

Authors:  Katharina U Vogel; Stephanie L Edelmann; Katharina M Jeltsch; Arianna Bertossi; Klaus Heger; Gitta A Heinz; Jessica Zöller; Sebastian C Warth; Kai P Hoefig; Claudia Lohs; Frauke Neff; Elisabeth Kremmer; Joel Schick; Dirk Repsilber; Arie Geerlof; Helmut Blum; Wolfgang Wurst; Mathias Heikenwälder; Marc Schmidt-Supprian; Vigo Heissmeyer
Journal:  Immunity       Date:  2013-04-11       Impact factor: 31.745

8.  Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.

Authors:  Kathrin Leppek; Johanna Schott; Sonja Reitter; Fabian Poetz; Ming C Hammond; Georg Stoecklin
Journal:  Cell       Date:  2013-05-09       Impact factor: 41.582

9.  ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.

Authors:  Erica L Stone; Marion Pepper; Carol D Katayama; Yann M Kerdiles; Chen-Yen Lai; Elizabeth Emslie; Yin C Lin; Edward Yang; Ananda W Goldrath; Ming O Li; Doreen A Cantrell; Stephen M Hedrick
Journal:  Immunity       Date:  2015-02-17       Impact factor: 31.745

10.  A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin.

Authors:  Annamaria Sgromo; Tobias Raisch; Praveen Bawankar; Dipankar Bhandari; Ying Chen; Duygu Kuzuoğlu-Öztürk; Oliver Weichenrieder; Elisa Izaurralde
Journal:  Nat Commun       Date:  2017-02-06       Impact factor: 14.919
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  1 in total

1.  Deiminated proteins in extracellular vesicles and serum of llama (Lama glama)-Novel insights into camelid immunity.

Authors:  Michael F Criscitiello; Igor Kraev; Sigrun Lange
Journal:  Mol Immunol       Date:  2019-11-13       Impact factor: 4.407
  1 in total

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