Jinglan Huang1, Bingyao Kang2, Yi Qu1, Dezhi Mu3. 1. Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. 2. Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.Ïkangbingyao2016@163.com. 3. Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.mudz@scu.edu.cn.
Abstract
Objective: To investigate the protective effect of the exosome on the organ damage induced by ische-mia-reperfusion (I/R) so as to provide a new way for the treatment of I/R damage. Methods: The literature related to the treatment of I/R damage was reviewed and analyzed. Results: The exosome volume is small and it is present in blood, cerebrospinal fluid, and urine, which has the function to cross the blood-brain barrier, and protect the heart, brain and other organs after I/R damage. Conclusion: Exosome is a new material for the treatment of I/R organ injury, and it is important to understand the protective effect and possible mechanism.
Objective: To investigate the protective effect of the exosome on the organ damage induced by ische-mia-reperfusion (I/R) so as to provide a new way for the treatment of I/R damage. Methods: The literature related to the treatment of I/R damage was reviewed and analyzed. Results: The exosome volume is small and it is present in blood, cerebrospinal fluid, and urine, which has the function to cross the blood-brain barrier, and protect the heart, brain and other organs after I/R damage. Conclusion: Exosome is a new material for the treatment of I/R organ injury, and it is important to understand the protective effect and possible mechanism.
Entities:
Keywords:
Exosome; ischemia-reperfusion; organ injury; treatment
Authors: Jing-Lan Huang; Yi Qu; Jun Tang; Rong Zou; Shi-Ping Li; Ya-Fei Li; Li Zhang; Bin Xia; De-Zhi Mu Journal: Zhongguo Dang Dai Er Ke Za Zhi Date: 2018-05