| Literature DB >> 2979848 |
B Chauffert1, T Shimizu, A Caignard, A Hammann, P Genne, H Pelletier, M S Martin.
Abstract
A simple model for liver metastasis from colon cancer resulted from the intraportal injection of 2 x 10(7) highly tumorigenic DHD/K12/PROb cells into syngeneic BDIX rats. Early detection and development of cancer invasion were studied by conventional microscopy and immunoenzymatic staining using a specific monoclonal antibody. Metastases developed either from isolated cancer cells early disseminated in sinusoid network or from intraportal microthrombi. An intense immune reaction developed until day 15 after injection but decreased and disappeared at the latest stages of evolution.Entities:
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Year: 1988 PMID： 2979848
Source DB: PubMed Journal: In Vivo ISSN： 0258-851X Impact factor: 2.155