X F Qiao 1 , X Li 2 . Show Affiliations »
Abstract
Objective:To evaluate the clinical effect of auricular keloids resection combined with local injection of glucocorticoid and superficial X-ray treatment in order to identify a surgery-based, personalized, comprehensive treatment system.Method:One hundred and sixty patients with auricular keloids were divided into four groups: surgery group, surgery combined with local injection of glucocorticoid group, surgery combined with superficial X-ray group and surgery combined with glucocorticoid and electron irradiation group (Triple therapy group). These groups were followed up for one year. Based on Darzi's criterion of keloid curative effect, the effect was judged and analyzed statistically.Result:One year after operation, the effective rate of the surgery group was 52.5%, that of the surgery combined with glucocorticoid injection group was 80.0%, that of the surgery combined with the superficial X-ray group was 82.5%, and that of the triple therapy group was about 97.5%. The simple surgery group was significantly lower than the surgery combined with glucocorticoid injection group, the operation combined with superficial X-ray group and triple therapy group (P< 0.01); the triple therapy group was better than the surgery combined with superficial X-ray group and surgery combined with glucocorticoid injection group, showing statistically significant differences (P< 0.05); There was no statistical difference (P> 0.05) between the surgery combined with glucocorticoid injection group and the surgery combined with superficial X-ray group. Conclusion: In the auricular keloids treatment, surgical resection with a poor curative effect is not recommended; triple therapy, which is better surgery combined with glucocorticoid local injection and surgery combined with superficial X-ray, should be used as the first line treatment. The overall response rate of surgery combined with glucocorticoid local injection and surgery combined with superficial X-ray is satisfactory. It should be individualized for use depending upon the situation. Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.
Objective:To evaluate the clinical effect of auricular keloids resection combined with local injection of glucocorticoid and superficial X-ray treatment in order to identify a surgery-based, personalized, comprehensive treatment system.Method:One hundred and sixty patients with auricular keloids were divided into four groups: surgery group, surgery combined with local injection of glucocorticoid group, surgery combined with superficial X-ray group and surgery combined with glucocorticoid and electron irradiation group (Triple therapy group). These groups were followed up for one year. Based on Darzi's criterion of keloid curative effect, the effect was judged and analyzed statistically.Result:One year after operation, the effective rate of the surgery group was 52.5%, that of the surgery combined with glucocorticoid injection group was 80.0%, that of the surgery combined with the superficial X-ray group was 82.5%, and that of the triple therapy group was about 97.5%. The simple surgery group was significantly lower than the surgery combined with glucocorticoid injection group, the operation combined with superficial X-ray group and triple therapy group (P< 0.01); the triple therapy group was better than the surgery combined with superficial X-ray group and surgery combined with glucocorticoid injection group, showing statistically significant differences (P< 0.05); There was no statistical difference (P> 0.05) between the surgery combined with glucocorticoid injection group and the surgery combined with superficial X-ray group. Conclusion: In the auricular keloids treatment, surgical resection with a poor curative effect is not recommended; triple therapy, which is better surgery combined with glucocorticoid local injection and surgery combined with superficial X-ray, should be used as the first line treatment. The overall response rate of surgery combined with glucocorticoid local injection and surgery combined with superficial X-ray is satisfactory. It should be individualized for use depending upon the situation. Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.
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Keywords:
auricular keloids ; betamethason; radiotherapy; superficial X-ray; surgery
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Year: 2017
PMID: 29798227 DOI: 10.13201/j.issn.1001-1781.2017.17.011
Source DB: PubMed Journal: Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ISSN: 1001-1781