| Literature DB >> 29797125 |
V Z Agrba1, D D Karal-Ogly2, T E Gvozdik2, P A Kaplanyan2, N P Demenkova2, I A Gvaramiya2, E I Mukhametzyanova2, O A Shamsutdinova2, Yu P Chuguev2, S Sh Kal'sina2, A G Konoplyannikov2, D E Araviashvili2, I N Klots2, B A Lapin2.
Abstract
Three injections of doxorubicin to rhesus macaques cause severe intoxication, characterized by anemia, cachexia, and degeneration of the viscera. The life span of monkeys injected with the drug and receiving after 24 h mesenchymal stem cell transplantation varied from 96 to 120 days in comparison with 50-74 days in animals receiving stem cells before doxorubicin. Controls received doxorubicin and saline; the lifespan of one monkey was 24 days, of the other - 1 year and 8 months. The increase in activity of proinflammatory cytokine IL-6 was paralleled by an increase in the level of C-reactive protein.Entities:
Keywords: B lymphocytes; cytokines; doxorubicin; monkeys; stem cells
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Year: 2018 PMID： 29797125 DOI： 10.1007/s10517-018-4108-8
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804